deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT01409200

Antiandrogen Therapy With or Without Axitinib Before Surgery in Treating Patients With Previously Untreated Prostate Cancer With Known or Suspected Lymph Node Metastasis

Pre-Surgical Androgen Deprivation Therapy With or Without Axitinib in Previously Untreated Prostate Cancer Patients With Known or Suspected Lymph Node Metastasis

Sponsor: M.D. Anderson Cancer Center

Conditions Metastatic Malignant Neoplasm in Lymph Node Prostate Ductal Adenocarcinoma Stage III Prostate Adenocarcinoma AJCC v7 Stage IV Prostate Adenocarcinoma AJCC v7
Interventions Antiandrogen Therapy Axitinib Radical Prostatectomy Regional Lymph Node Dissection
Updated 24 times since 2017 Last updated: Feb 27, 2026 Started: Mar 26, 2012 Primary completion: Feb 5, 2026 Completion: Feb 5, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Metastatic Malignant Neoplasm in Lymph Node and Prostate Ductal Adenocarcinoma, this trial is completed. The trial is conducted by M.D. Anderson Cancer Center and has accumulated 24 data snapshots since 2012. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jul 2017 · 5 months · monthly snapshot~Jul 2017 – ~Jun 2018 · 11 months · monthly snapshot~Jun 2018 – ~Jan 2019 · 7 months · monthly snapshot~Jan 2019 – ~Jun 2019 · 5 months · monthly snapshot~Jun 2019 – ~Mar 2020 · 9 months · monthly snapshot~Mar 2020 – ~Jan 2021 · 10 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Apr 2022 · 7 months · monthly snapshot~Apr 2022 – ~Sep 2022 · 5 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~Jun 2023 · 5 months · monthly snapshot~Jun 2023 – ~Nov 2023 · 5 months · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jun 2024 · 6 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Jun 2025 · 6 months · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Jan 2026 · 6 months · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshot~Mar 2026 – present · 4 months · monthly snapshot

Change History

24 versions recorded

  1. Mar 2026 — Present [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  2. Feb 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Jan 2026 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE2

  5. Jun 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 19 earlier versions

  1. Dec 2024 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Dec 2023 — Jun 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE2

  7. Jun 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  8. Jan 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2

  9. Sep 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE2

  10. Apr 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  11. Sep 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

  12. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  13. Mar 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  14. Jun 2019 — Mar 2020 [monthly]

    Active Not Recruiting PHASE2

  15. Jan 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  16. Jun 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  17. Jul 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  18. Feb 2017 — Jul 2017 [monthly]

    Recruiting PHASE2

  19. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Mar 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations