deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT02893917

Testing Two Oral Drugs Combination (Cediranib and Olaparib) Compared to a Single Drug (Olaparib) for Men With Advanced Prostate Cancer

A Randomized Phase 2 Study of Cediranib in Combination With Olaparib Versus Olaparib Alone in Men With Metastatic Castration Resistant Prostate Cancer

Sponsor: National Cancer Institute (NCI)

Conditions Advanced Prostate Adenocarcinoma With Neuroendocrine Differentiation Castration-Resistant Prostate Carcinoma Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation Metastatic Prostate Carcinoma Prostate Adenocarcinoma With Neuroendocrine Differentiation Stage IV Prostate Adenocarcinoma AJCC v7
Interventions Cediranib Olaparib
Updated 53 times since 2017 Last updated: Mar 12, 2026 Started: Aug 11, 2017 Primary completion: Mar 14, 2023 Completion: Jun 18, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Advanced Prostate Adenocarcinoma With Neuroendocrine Differentiation and Castration-Resistant Prostate Carcinoma and is currently ongoing. National Cancer Institute (NCI) leads this study, which shows 53 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Nov 2017 · 3 months · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Feb 2018 · 2 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Dec 2018 · 3 months · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~Jul 2019 · 4 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Sep 2021 · 7 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Feb 2022 · 3 months · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~Jul 2022 · 3 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Aug 2023 · 6 months · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Dec 2023 · 2 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Apr 2025 · 6 months · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jul 2025 · 2 months · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Mar 2026 · 7 months · monthly snapshot~Mar 2026 – present · 4 months · monthly snapshot

Change History

53 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Aug 2025 — Mar 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE2

  4. May 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 48 earlier versions

  1. Oct 2024 — Apr 2025 [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Dec 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Oct 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE2

  7. Aug 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

  8. Feb 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE2

  9. Dec 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

  10. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

  11. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  12. Apr 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

  13. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

  14. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE2

  15. Nov 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE2

  16. Sep 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE2

  17. Feb 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  18. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE2

  19. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  20. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE2

  21. Aug 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

  22. Jun 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE2

  23. Apr 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE2

  24. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE2

  25. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE2

  26. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE2

  27. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE2

  28. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE2

  29. Oct 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE2

  30. Aug 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE2

  31. Jul 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE2

  32. Mar 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  33. Jan 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  34. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  35. Sep 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  36. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  37. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  38. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  39. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  40. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE2

  41. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE2

  42. Dec 2017 — Feb 2018 [monthly]

    Recruiting PHASE2

  43. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  44. Aug 2017 — Nov 2017 [monthly]

    Recruiting PHASE2

  45. Jun 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  46. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  47. Feb 2017 — May 2017 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  48. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Boston, United States , Columbus, United States , Detroit, United States , Farmington Hills, United States , La Jolla, United States , Nashville, United States , New Haven, United States , Pittsburgh, United States , Richmond, United States , Sacramento, United States and 2 more locations