deltatrials
Completed PHASE2 INTERVENTIONAL 5-arm NCT01415882

Ixazomib Citrate in Treating Patients With Relapsed Multiple Myeloma That Is Not Refractory to Bortezomib

Phase 2 Trial of Ixazomib Combinations in Patients With Relapsed Multiple Myeloma

Sponsor: Mayo Clinic

Conditions Recurrent Plasma Cell Myeloma Refractory Plasma Cell Myeloma
Interventions Cyclophosphamide Daratumumab Dexamethasone Ixazomib Citrate Laboratory Biomarker Analysis
Updated 26 times since 2017 Last updated: Aug 19, 2025 Started: Jan 31, 2012 Primary completion: Apr 21, 2023 Completion: Apr 30, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT01415882, this PHASE2 trial focuses on Recurrent Plasma Cell Myeloma and Refractory Plasma Cell Myeloma and remains completed. Sponsored by Mayo Clinic, it has been updated 26 times since 2012, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Sep 2017 · 7 months · monthly snapshot~Sep 2017 – ~May 2018 · 8 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Feb 2019 · 8 months · monthly snapshot~Feb 2019 – ~May 2019 · 3 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jan 2020 · 7 months · monthly snapshot~Jan 2020 – ~Dec 2020 · 11 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Oct 2021 · 5 months · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Mar 2022 · 4 months · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Mar 2023 · 4 months · monthly snapshot~Mar 2023 – ~Oct 2023 · 7 months · monthly snapshot~Oct 2023 – ~Jul 2024 · 9 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Mar 2025 · 5 months · monthly snapshot~Mar 2025 – ~Oct 2025 · 7 months · monthly snapshot~Oct 2025 – present · 9 months · monthly snapshot

Change History

26 versions recorded

  1. Oct 2025 — Present [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  2. Mar 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Oct 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 21 earlier versions

  1. Oct 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Mar 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

  3. Nov 2022 — Mar 2023 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE2

  5. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  6. Apr 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE2

  7. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  8. Nov 2021 — Mar 2022 [monthly]

    Recruiting PHASE2

  9. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  10. May 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  11. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE2

  12. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  13. Jan 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  14. Jun 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  15. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  16. Feb 2019 — May 2019 [monthly]

    Recruiting PHASE2

  17. Jun 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  18. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  19. Sep 2017 — May 2018 [monthly]

    Recruiting PHASE2

  20. Feb 2017 — Sep 2017 [monthly]

    Recruiting PHASE2

  21. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Jan 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Mayo Clinic
Data source: Mayo Clinic

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations