deltatrials
Completed PHASE1 INTERVENTIONAL 7-arm NCT01607905

Safety Study of KPT-330 (Selinexor) in Patients With Advanced or Metastatic Solid Tumor Cancer

A Phase I Study of the Safety, Pharmacokinetics and Pharmacodynamics of Escalating Doses of the Selective Inhibitor of Nuclear Export/SINE Compound KPT-330 in Patients With Advanced or Metastatic Solid Tumor Malignancies

Sponsor: Karyopharm Therapeutics Inc

Conditions Solid Tumor
Interventions Acetaminophen Selinexor
Updated 12 times since 2017 Last updated: Jan 24, 2023 Started: Jun 18, 2012 Primary completion: Mar 15, 2016 Completion: Mar 15, 2016
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Solid Tumor, this trial is completed. The trial is conducted by Karyopharm Therapeutics Inc and has accumulated 12 data snapshots since 2012. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotActive Not Recruiting~Feb 2017 – ~May 2017 · 3 months · monthly snapshotActive Not Recruiting~May 2017 – ~Jun 2018 · 13 months · monthly snapshotCompleted~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshotCompleted~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshotCompleted~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshotCompleted~Sep 2018 – ~Jan 2021 · 28 months · monthly snapshotCompleted~Jan 2021 – ~May 2021 · 4 months · monthly snapshotCompleted~May 2021 – ~Feb 2023 · 21 months · monthly snapshotCompleted~Feb 2023 – ~Jul 2024 · 17 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – present · 22 months · monthly snapshotCompleted

Change History

12 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Feb 2023 — Jul 2024 [monthly]

    Completed PHASE1

  4. May 2021 — Feb 2023 [monthly]

    Completed PHASE1

  5. Jan 2021 — May 2021 [monthly]

    Completed PHASE1

▶ Show 7 earlier versions

  1. Sep 2018 — Jan 2021 [monthly]

    Completed PHASE1

  2. Aug 2018 — Sep 2018 [monthly]

    Completed PHASE1

  3. Jul 2018 — Aug 2018 [monthly]

    Completed PHASE1

  4. Jun 2018 — Jul 2018 [monthly]

    Completed PHASE1

  5. May 2017 — Jun 2018 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  6. Feb 2017 — May 2017 [monthly]

    Active Not Recruiting PHASE1

  7. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE1

    First recorded

Jun 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Karyopharm Therapeutics Inc
Data source: Karyopharm Therapeutics Inc

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations