deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 1-arm NCT02186834

Selinexor (KPT-330) and Liposomal Doxorubicin For Relapsed and Refractory Multiple Myeloma

Investigator-Initiated Phase I/II Clinical Trial of Selinexor (KPT-330) and Liposomal Doxorubicin for Relapsed and Refractory Multiple Myeloma

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Conditions Multiple Myeloma
Interventions Dexamethasone Liposomal doxorubicin Selinexor
Updated 26 times since 2017 Last updated: Dec 29, 2022 Started: Sep 23, 2014 Primary completion: Nov 8, 2017 Completion: Mar 14, 2018
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02186834, this PHASE1/PHASE2 trial focuses on Multiple Myeloma and remains completed. Sponsored by H. Lee Moffitt Cancer Center and Research Institute, it has been updated 26 times since 2014, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~May 2017 · 2 months · monthly snapshot~May 2017 – ~Oct 2017 · 5 months · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Mar 2019 · 6 months · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Aug 2019 · 4 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Jan 2020 · 4 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Jun 2020 · 4 months · monthly snapshot~Jun 2020 – ~Dec 2020 · 6 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~Jun 2022 · 4 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Jul 2024 · 17 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 24 months · monthly snapshot

Change History

26 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  3. Feb 2023 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

  4. Sep 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  5. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

▶ Show 21 earlier versions

  1. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  2. Feb 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  3. Sep 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  4. Apr 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  5. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  6. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  7. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  8. Jun 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  9. Feb 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  10. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  11. Sep 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  12. Aug 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  13. Apr 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  14. Mar 2019 — Apr 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  15. Sep 2018 — Mar 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  16. Jun 2018 — Sep 2018 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  17. Oct 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  18. May 2017 — Oct 2017 [monthly]

    Recruiting PHASE1_PHASE2

  19. Mar 2017 — May 2017 [monthly]

    Recruiting PHASE1_PHASE2

  20. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE1_PHASE2

  21. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Sep 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • H. Lee Moffitt Cancer Center and Research Institute
  • Karyopharm Therapeutics Inc
Data source: H. Lee Moffitt Cancer Center and Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations