deltatrials
Completed PHASE2 INTERVENTIONAL 3-arm NCT01640080

A Study of the Efficacy of Intravenous Esketamine in Adult Patients With Treatment-Resistant Depression

A Double-Blind, Double-Randomization, Placebo-Controlled Study of the Efficacy of Intravenous Esketamine in Adult Subjects With Treatment-Resistant Depression

Sponsor: Janssen Research & Development, LLC

Conditions Major Depressive Disorder
Interventions Esketamine Placebo
Updated 10 times since 2017 Last updated: Apr 25, 2025 Started: Jun 27, 2012 Primary completion: Jun 3, 2013 Completion: Jun 3, 2013
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Major Depressive Disorder, this trial is completed. The trial is conducted by Janssen Research & Development, LLC and has accumulated 10 data snapshots since 2012. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotCompleted~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshotCompleted~Jun 2018 – ~Jul 2020 · 25 months · monthly snapshotCompleted~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshotCompleted~Jan 2021 – ~Apr 2022 · 15 months · monthly snapshotCompleted~Apr 2022 – ~Jul 2024 · 27 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~May 2025 · 8 months · monthly snapshotCompleted~May 2025 – ~Sep 2025 · 4 months · monthly snapshotCompleted~Sep 2025 – present · 12 months · monthly snapshotCompleted

Change History

10 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. May 2025 — Sep 2025 [monthly]

    Completed PHASE2

  3. Sep 2024 — May 2025 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  5. Apr 2022 — Jul 2024 [monthly]

    Completed PHASE2

▶ Show 5 earlier versions

  1. Jan 2021 — Apr 2022 [monthly]

    Completed PHASE2

  2. Jul 2020 — Jan 2021 [monthly]

    Completed PHASE2

  3. Jun 2018 — Jul 2020 [monthly]

    Completed PHASE2

  4. Feb 2017 — Jun 2018 [monthly]

    Completed PHASE2

  5. Jan 2017 — Feb 2017 [monthly]

    Completed PHASE2

    First recorded

Jun 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Research & Development, LLC
Data source: Janssen Research & Development, LLC

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations