Completed PHASE3 INTERVENTIONAL 2-arm NCT01690221

Efficacy and Safety Study With Diltiazem Hydrochloride Cream to Treat Anal Fissures

A Phase 3B, Randomized, Double-Blind, Placebo-Controlled, Parallel-Treatment Group, Multicenter Efficacy and Safety Study of Topical Diltiazem Hydrochloride 2% Cream in Subjects With Anal Fissure

Sponsor: Ventrus Biosciences, Inc

Conditions Chronic Anal Fissures

Interventions Placebo VEN 307

Updated 7 times since 2017 Last updated: Jan 22, 2014 Started: Oct 31, 2012 Primary completion: Dec 31, 2013 Completion: Jan 31, 2014

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Chronic Anal Fissures and is currently completed. Ventrus Biosciences, Inc leads this study, which shows 7 recorded versions since 2012 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3

▶ Show 2 earlier versions

Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Oct 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Ventrus Biosciences, Inc

Data source: Ventrus Biosciences, Inc

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Annapolis, United States , Anniston, United States , Arlington Heights, United States , Atlanta, United States , Augusta, United States , Aventura, United States , Baltimore, United States , Bellevue, United States , Bend, United States , Boone, United States and 77 more locations