Completed PHASE3 INTERVENTIONAL 4-arm NCT00004259

Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas

A Phase III Randomized Study (Phase I Closed) of Radiation Therapy and Temozolomide Versus Radiation Therapy and Nitrosourea for Anaplastic Astrocytoma And Mixed Anaplastic Oligoastrocytoma (Astrocytoma Dominant)

Sponsor: Eastern Cooperative Oncology Group

Conditions Brain and Central Nervous System Tumors

Interventions BCNU 150mg/m2 BCNU 200mg/m2 BCNU 80mg/m2 CCNU TMZ 150mg/m2 six 6-week cycles TMZ 150mg/m2 six 8-week cycles TMZ 200mg/m2 radiation therapy

Updated 12 times since 2017 Last updated: Aug 28, 2019 Started: Jun 30, 2000 Primary completion: Feb 1, 2015 Completion: May 14, 2018

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00004259, this PHASE3 trial focuses on Brain and Central Nervous System Tumors and remains completed. Sponsored by Eastern Cooperative Oncology Group, it has been updated 12 times since 2000, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

12 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Dec 2021 — Jul 2024 [monthly]

Completed PHASE3
Jan 2021 — Dec 2021 [monthly]

Completed PHASE3

▶ Show 7 earlier versions

Oct 2019 — Jan 2021 [monthly]

Completed PHASE3
Jul 2018 — Oct 2019 [monthly]

Completed PHASE3

Status: Active Not Recruiting → Completed
Jun 2018 — Jul 2018 [monthly]

Active Not Recruiting PHASE3
Feb 2018 — Jun 2018 [monthly]

Active Not Recruiting PHASE3
Dec 2017 — Feb 2018 [monthly]

Active Not Recruiting PHASE3
Feb 2017 — Dec 2017 [monthly]

Active Not Recruiting PHASE3
Jan 2017 — Feb 2017 [monthly]

Active Not Recruiting PHASE3

First recorded

Jun 2000

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Eastern Cooperative Oncology Group
NRG Oncology
National Cancer Institute (NCI)
North Central Cancer Treatment Group
Radiation Therapy Oncology Group

Data source: Radiation Therapy Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States , Ames, United States , Appleton, United States , Asheville, United States , Baltimore, United States , Billings, United States , Bloomington, United States , Boca Raton, United States , Canton, United States , Carthage, United States and 64 more locations