deltatrials
Active Not Recruiting PHASE2/PHASE3 INTERVENTIONAL 8-arm NCT01760005

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001 (DIAN-TU)

A Phase II/III Multicenter Randomized, Double-Blind, Placebo-Controlled Platform Trial of Potential Disease Modifying Therapies Utilizing Biomarker, Cognitive, and Clinical Endpoints in Dominantly Inherited Alzheimer's Disease

Sponsor: Accelerating Medicines Partnership (AMP)

Updated 28 times since 2017 Last updated: Feb 11, 2026 Started: Dec 31, 2012 Primary completion: Apr 30, 2028 Completion: Jul 31, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2/PHASE3 clinical study on Alzheimers Disease and Alzheimers Disease, Familial, this trial is ongoing. The trial is conducted by Accelerating Medicines Partnership (AMP) and has accumulated 28 data snapshots since 2012. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Aug 2017 · 6 months · monthly snapshot~Aug 2017 – ~Oct 2017 · 2 months · monthly snapshot~Oct 2017 – ~Feb 2018 · 4 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Mar 2019 · 8 months · monthly snapshot~Mar 2019 – ~Aug 2019 · 5 months · monthly snapshot~Aug 2019 – ~Nov 2019 · 3 months · monthly snapshot~Nov 2019 – ~May 2020 · 6 months · monthly snapshot~May 2020 – ~Sep 2020 · 4 months · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Dec 2022 · 12 months · monthly snapshot~Dec 2022 – ~May 2023 · 5 months · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Nov 2023 · 5 months · monthly snapshot~Nov 2023 – ~Jun 2024 · 7 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~May 2025 · 8 months · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – ~Feb 2026 · 2 months · monthly snapshot~Feb 2026 – present · 4 months · monthly snapshot

Change History

28 versions recorded
  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE2/PHASE3

  2. Dec 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2/PHASE3

    Status: RecruitingActive Not Recruiting

  3. Sep 2025 — Dec 2025 [monthly]

    Recruiting PHASE2/PHASE3

  4. May 2025 — Sep 2025 [monthly]

    Recruiting PHASE2/PHASE3

  5. Sep 2024 — May 2025 [monthly]

    Recruiting PHASE2/PHASE3

Show 23 earlier versions
  1. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2/PHASE3

  2. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2/PHASE3

    Phase: PHASE2_PHASE3PHASE2/PHASE3

  3. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2_PHASE3

  4. Nov 2023 — Jun 2024 [monthly]

    Recruiting PHASE2_PHASE3

  5. Jun 2023 — Nov 2023 [monthly]

    Recruiting PHASE2_PHASE3

  6. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE2_PHASE3

  7. Dec 2022 — May 2023 [monthly]

    Recruiting PHASE2_PHASE3

  8. Dec 2021 — Dec 2022 [monthly]

    Recruiting PHASE2_PHASE3

  9. Sep 2021 — Dec 2021 [monthly]

    Recruiting PHASE2_PHASE3

  10. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE2_PHASE3

  11. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE2_PHASE3

    Status: CompletedRecruiting

  12. Sep 2020 — Nov 2020 [monthly]

    Completed PHASE2_PHASE3

    Status: RecruitingCompleted

  13. May 2020 — Sep 2020 [monthly]

    Recruiting PHASE2_PHASE3

  14. Nov 2019 — May 2020 [monthly]

    Recruiting PHASE2_PHASE3

  15. Aug 2019 — Nov 2019 [monthly]

    Recruiting PHASE2_PHASE3

    Status: Active Not RecruitingRecruiting

  16. Mar 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  17. Jul 2018 — Mar 2019 [monthly]

    Active Not Recruiting PHASE2_PHASE3

    Status: RecruitingActive Not Recruiting

  18. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2_PHASE3

  19. Feb 2018 — Jun 2018 [monthly]

    Recruiting PHASE2_PHASE3

  20. Oct 2017 — Feb 2018 [monthly]

    Recruiting PHASE2_PHASE3

    Status: Active Not RecruitingRecruiting

  21. Aug 2017 — Oct 2017 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  22. Feb 2017 — Aug 2017 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  23. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE2_PHASE3

    First recorded

Dec 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Accelerating Medicines Partnership (AMP)
  • Alzheimer's Association
  • Avid Radiopharmaceuticals
  • Eisai Inc.
  • Eli Lilly and Company
  • Hoffmann-La Roche
  • Janssen, LP
  • National Institute on Aging (NIA)
  • Washington University School of Medicine
Data source: Washington University School of Medicine

For direct contact, visit the study record on ClinicalTrials.gov .