deltatrials
Terminated NA INTERVENTIONAL 1-arm NCT01954576

NovoTTF Therapy in Treating Patients With Recurrent Glioblastoma Multiforme

A Phase II Study of the Optune System, Enhanced by Genomic Analysis to Identify the Genetic Signature of Response in the Treatment of Recurrent Glioblastoma Multiforme

Sponsor: NovoCure Ltd.

Conditions Brain Neoplasms Glioblastoma
Interventions Laboratory biomarker analysis NovoTTF-100A Quality-of-life assessment
Updated 24 times since 2017 Last updated: Oct 27, 2022 Started: Oct 10, 2013 Primary completion: May 14, 2021 Completion: May 14, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Poor accrual; Avastin refractory patients not feasible given treatment paradigm in these patients.

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A NA clinical study on Brain Neoplasms and Glioblastoma, this trial is terminated or withdrawn. The trial is conducted by NovoCure Ltd. and has accumulated 24 data snapshots since 2013. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~Jun 2017 · 2 months · monthly snapshot~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Oct 2017 · 2 months · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Jan 2019 · 3 months · monthly snapshot~Jan 2019 – ~Apr 2019 · 3 months · monthly snapshot~Apr 2019 – ~Sep 2019 · 5 months · monthly snapshot~Sep 2019 – ~Dec 2019 · 3 months · monthly snapshot~Dec 2019 – ~Apr 2020 · 4 months · monthly snapshot~Apr 2020 – ~Oct 2020 · 6 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Jan 2022 · 4 months · monthly snapshot~Jan 2022 – ~Nov 2022 · 10 months · monthly snapshot~Nov 2022 – ~Jul 2024 · 20 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

24 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated NA

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated NA

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated NA

  4. Nov 2022 — Jul 2024 [monthly]

    Terminated NA

  5. Jan 2022 — Nov 2022 [monthly]

    Terminated NA

    Status: Active Not Recruiting → Terminated

▶ Show 19 earlier versions

  1. Sep 2021 — Jan 2022 [monthly]

    Active Not Recruiting NA

    Status: Recruiting → Active Not Recruiting

  2. Jan 2021 — Sep 2021 [monthly]

    Recruiting NA

  3. Oct 2020 — Jan 2021 [monthly]

    Recruiting NA

  4. Apr 2020 — Oct 2020 [monthly]

    Recruiting NA

  5. Dec 2019 — Apr 2020 [monthly]

    Recruiting NA

  6. Sep 2019 — Dec 2019 [monthly]

    Recruiting NA

  7. Apr 2019 — Sep 2019 [monthly]

    Recruiting NA

  8. Jan 2019 — Apr 2019 [monthly]

    Recruiting NA

  9. Oct 2018 — Jan 2019 [monthly]

    Recruiting NA

  10. Aug 2018 — Oct 2018 [monthly]

    Recruiting NA

  11. Jun 2018 — Aug 2018 [monthly]

    Recruiting NA

  12. Oct 2017 — Jun 2018 [monthly]

    Recruiting NA

  13. Aug 2017 — Oct 2017 [monthly]

    Recruiting NA

    Status: Active Not Recruiting → Recruiting

  14. Jul 2017 — Aug 2017 [monthly]

    Active Not Recruiting NA

  15. Jun 2017 — Jul 2017 [monthly]

    Active Not Recruiting NA

  16. Apr 2017 — Jun 2017 [monthly]

    Active Not Recruiting NA

    Phase: PHASE2 → NA

  17. Mar 2017 — Apr 2017 [monthly]

    Active Not Recruiting PHASE2

  18. Feb 2017 — Mar 2017 [monthly]

    Active Not Recruiting PHASE2

  19. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE2

    First recorded

Oct 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • NovoCure Ltd.
  • University of Florida
  • Washington University School of Medicine
Data source: University of Florida

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations