deltatrials
Terminated PHASE2 INTERVENTIONAL 1-arm NCT02663271

TTFields and Pulsed Bevacizumab for Recurrent Glioblastoma

A Phase 2, Multi-center, Single Arm, Histologically Controlled Study Testing the Combination of TTFields and Pulsed Bevacizumab Treatment in Patients With Bevacizumab-refractory Recurrent Glioblastoma

Sponsor: NovoCure Ltd.

Conditions GBM Glioblastoma Glioblastoma Multiforme Malignant Glioma
Interventions Bevacizumab Brain MRI Optune Quality of Life Questionnaires
Updated 24 times since 2017 Last updated: May 31, 2022 Started: Dec 19, 2016 Primary completion: Jun 11, 2021 Completion: Jun 11, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

stagnant enrollment

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This PHASE2 trial investigates GBM and Glioblastoma and is currently terminated or withdrawn. NovoCure Ltd. leads this study, which shows 24 recorded versions since 2016 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~Jun 2017 · 2 months · monthly snapshot~Jun 2017 – ~Dec 2017 · 6 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Jan 2019 · 3 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~Sep 2019 · 5 months · monthly snapshot~Sep 2019 – ~Dec 2019 · 3 months · monthly snapshot~Dec 2019 – ~Mar 2020 · 3 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Dec 2020 · 8 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Jul 2024 · 24 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

24 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  4. Jul 2022 — Jul 2024 [monthly]

    Terminated PHASE2

  5. May 2022 — Jul 2022 [monthly]

    Terminated PHASE2

▶ Show 19 earlier versions

  1. Feb 2022 — May 2022 [monthly]

    Terminated PHASE2

  2. Sep 2021 — Feb 2022 [monthly]

    Terminated PHASE2

    Status: Recruiting → Terminated

  3. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  4. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  5. Apr 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  6. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  7. Dec 2019 — Mar 2020 [monthly]

    Recruiting PHASE2

  8. Sep 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  9. Apr 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  10. Feb 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  11. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  12. Oct 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  13. Aug 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  14. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  15. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  16. Jun 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  17. Apr 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  18. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE2

  19. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Dec 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • NovoCure Ltd.
  • University of Florida
Data source: University of Florida

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations