deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT01958593

Randomized, Double-blind, Controlled of MDMA-assisted Psychotherapy in 12 Subjects With PTSD

A Randomized, Double-Blind, Controlled Phase 2 Pilot Study of Manualized 3,4-methylenedioxymethamphetamine (MDMA)-Assisted Psychotherapy in 12 Subjects With Treatment-Resistant Posttraumatic Stress Disorder (PTSD) - Canada

Sponsor: Lykos Therapeutics

Conditions Posttraumatic Stress Disorder
Interventions Midomafetamine HCl Placebo Psychotherapy
Updated 23 times since 2017 Last updated: May 23, 2025 Started: Oct 14, 2014 Primary completion: Sep 10, 2015 Completion: Oct 17, 2016
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

This pilot study was terminated early by sponsor due to insufficient rate of accrual.

Other terminated trials from Lykos Therapeutics

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A PHASE2 clinical study on Posttraumatic Stress Disorder, this trial is terminated or withdrawn. The trial is conducted by Lykos Therapeutics and has accumulated 23 data snapshots since 2014. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~Aug 2017 · 4 months · monthly snapshot~Aug 2017 – ~Dec 2017 · 4 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Jan 2021 · 31 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Feb 2022 · 2 months · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~May 2022 · 2 months · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~May 2023 · 4 months · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Nov 2023 · 5 months · monthly snapshot~Nov 2023 – ~Feb 2024 · 3 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – present · 12 months · monthly snapshot

Change History

23 versions recorded

  1. Jul 2025 — Present [monthly]

    Terminated PHASE2

  2. Jun 2025 — Jul 2025 [monthly]

    Terminated PHASE2

  3. Sep 2024 — Jun 2025 [monthly]

    Terminated PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  5. Feb 2024 — Jul 2024 [monthly]

    Terminated PHASE2

▶ Show 18 earlier versions

  1. Nov 2023 — Feb 2024 [monthly]

    Terminated PHASE2

  2. Jun 2023 — Nov 2023 [monthly]

    Terminated PHASE2

  3. May 2023 — Jun 2023 [monthly]

    Terminated PHASE2

  4. Jan 2023 — May 2023 [monthly]

    Terminated PHASE2

  5. Dec 2022 — Jan 2023 [monthly]

    Terminated PHASE2

  6. Sep 2022 — Dec 2022 [monthly]

    Terminated PHASE2

  7. May 2022 — Sep 2022 [monthly]

    Terminated PHASE2

  8. Mar 2022 — May 2022 [monthly]

    Terminated PHASE2

  9. Feb 2022 — Mar 2022 [monthly]

    Terminated PHASE2

  10. Dec 2021 — Feb 2022 [monthly]

    Terminated PHASE2

  11. Sep 2021 — Dec 2021 [monthly]

    Terminated PHASE2

    Status: Completed → Terminated

  12. Jan 2021 — Sep 2021 [monthly]

    Completed PHASE2

  13. Jun 2018 — Jan 2021 [monthly]

    Completed PHASE2

  14. Dec 2017 — Jun 2018 [monthly]

    Completed PHASE2

  15. Aug 2017 — Dec 2017 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  16. Apr 2017 — Aug 2017 [monthly]

    Active Not Recruiting PHASE2

  17. Feb 2017 — Apr 2017 [monthly]

    Active Not Recruiting PHASE2

  18. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE2

    First recorded

Oct 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Lykos Therapeutics
Data source: Lykos Therapeutics

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations