deltatrials
Completed PHASE1 INTERVENTIONAL 3-arm NCT01969643

A Safety Study of SGN-LIV1A in Breast Cancer Patients

A Phase 1, Open-Label, Dose-Escalation Study to Evaluate the Safety and Tolerability of SGN-LIV1A in Patients With Metastatic Breast Cancer

Sponsor: Seagen Inc.

Conditions HER2 Mutations Breast Neoplasms HER2 Positive Breast Neoplasms Hormone Receptor Positive Breast Neoplasms Triple Negative Breast Neoplasms
Interventions Trastuzumab ladiratuzumab vedotin
Updated 47 times since 2017 Last updated: Mar 3, 2023 Started: Oct 22, 2013 Primary completion: Feb 4, 2023 Completion: Feb 4, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT01969643, this PHASE1 trial focuses on HER2 Mutations Breast Neoplasms and HER2 Positive Breast Neoplasms and remains completed. Sponsored by Seagen Inc., it has been updated 47 times since 2013, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Sep 2017 · 7 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Mar 2018 · 5 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Apr 2022 · 3 months · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Apr 2023 · 3 months · monthly snapshot~Apr 2023 – ~Jul 2024 · 15 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

47 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  4. Apr 2023 — Jul 2024 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  5. Jan 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

▶ Show 42 earlier versions

  1. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE1

  2. Sep 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  3. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  4. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  5. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  6. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  7. Jan 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  8. Nov 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  9. Sep 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  10. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  11. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE1

  12. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  13. Sep 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  14. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  15. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  16. May 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  17. Mar 2020 — May 2020 [monthly]

    Recruiting PHASE1

  18. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  19. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  20. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  21. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  22. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  23. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  24. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  25. Jun 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  26. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  27. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1

  28. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  29. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

  30. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE1

  31. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

  32. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  33. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  34. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE1

  35. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  36. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  37. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

  38. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

  39. Oct 2017 — Mar 2018 [monthly]

    Recruiting PHASE1

  40. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE1

  41. Feb 2017 — Sep 2017 [monthly]

    Recruiting PHASE1

  42. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Oct 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Seagen Inc.
Data source: Seagen Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albuquerque, United States , Atlanta, United States , Aurora, United States , Baltimore, United States , Birmingham, United States , Boston, United States , Chicago, United States , Cleveland, United States , Dallas, United States , Detroit, United States and 23 more locations