deltatrials
Completed PHASE1 INTERVENTIONAL 7-arm NCT02658214

Durvalumab and Tremelimumab in Combination With First-Line Chemotherapy in Advanced Solid Tumors

A Phase Ib Study to Evaluate the Safety and Tolerability of Durvalumab and Tremelimumab in Combination With First-Line Chemotherapy in Patients With Advanced Solid Tumors.

Sponsor: AstraZeneca

Conditions Carcinoma, Pancreatic Ductal Carcinoma, Squamous Cell of Head and Neck Esophageal Squamous Cell Carcinoma Esophagogastric Junction Neoplasms Fallopian Tube Neoplasms Ovarian Neoplasms Peritoneal Neoplasms Small Cell Lung Carcinoma Stomach Neoplasms Triple Negative Breast Neoplasms
Interventions carboplatin + etoposide cisplatin + 5-fluorouracil (5FU) durvalumab gemcitabine + carboplatin nab-paclitaxel (paclitaxel-albumin) + carboplatin nab-paclitaxel (paclitaxel-albumin) + gemcitabine oxaliplatin + 5-fluorouracil (5FU) + leucovorin (calcium folinate/folinic acid) paclitaxel + carboplatin tremelimumab
Updated 21 times since 2017 Last updated: Aug 19, 2020 Started: Apr 28, 2016 Primary completion: Nov 14, 2019 Completion: Nov 14, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Carcinoma, Pancreatic Ductal and Carcinoma, Squamous Cell of Head and Neck, this trial is completed. The trial is conducted by AstraZeneca and has accumulated 21 data snapshots since 2016. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Oct 2017 · 5 months · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Jun 2019 · 3 months · monthly snapshot~Jun 2019 – ~Sep 2019 · 3 months · monthly snapshot~Sep 2019 – ~Jan 2020 · 4 months · monthly snapshot~Jan 2020 – ~Sep 2020 · 8 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 8 months · monthly snapshot

Change History

21 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  4. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE1

  5. Sep 2020 — Jan 2021 [monthly]

    Completed PHASE1

▶ Show 16 earlier versions

  1. Jan 2020 — Sep 2020 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Sep 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE1

  3. Jun 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE1

  4. Mar 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  5. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

  6. Dec 2018 — Feb 2019 [monthly]

    Recruiting PHASE1

  7. Oct 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  8. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE1

  9. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  10. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  11. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

  12. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

  13. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE1

  14. May 2017 — Oct 2017 [monthly]

    Recruiting PHASE1

    Status: Active Not Recruiting → Recruiting

  15. Feb 2017 — May 2017 [monthly]

    Active Not Recruiting PHASE1

  16. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE1

    First recorded

Apr 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
Data source: AstraZeneca

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations