deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT01984138

REVIVE: Replens Versus Intra-Vaginal Estrogen for the Treatment of Vaginal Dryness on Aromatase Inhibitor Therapy (REVIVE)

Sponsor: Polly A. Niravath, MD

Conditions Breast Cancer Estrogen Receptor Positive Breast Cancer
Interventions ESTRING Replens Vagifem
Updated 15 times since 2017 Last updated: Jan 26, 2026 Started: Sep 30, 2013 Primary completion: Jun 3, 2025 Completion: Jun 30, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Breast Cancer and Estrogen Receptor Positive Breast Cancer, this trial is ongoing. The trial is conducted by Polly A. Niravath, MD and has accumulated 15 data snapshots since 2013. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Mar 2019 · 9 months · monthly snapshot~Mar 2019 – ~Sep 2019 · 6 months · monthly snapshot~Sep 2019 – ~Jan 2021 · 16 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2022 · 13 months · monthly snapshot~Dec 2022 – ~Feb 2024 · 14 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~May 2025 · 8 months · monthly snapshot~May 2025 – ~Jan 2026 · 8 months · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

15 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Jan 2026 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  3. May 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Sep 2024 — May 2025 [monthly]

    Recruiting PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

▶ Show 10 earlier versions

  1. Feb 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  2. Dec 2022 — Feb 2024 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

  3. Nov 2021 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: Unknown Status → Active Not Recruiting

  4. Oct 2021 — Nov 2021 [monthly]

    Unknown Status PHASE2

    Status: Recruiting → Unknown Status

  5. Jan 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  6. Sep 2019 — Jan 2021 [monthly]

    Recruiting PHASE2

  7. Mar 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  8. Jun 2018 — Mar 2019 [monthly]

    Recruiting PHASE2

  9. Feb 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  10. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Sep 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Polly A. Niravath, MD
Data source: The Methodist Hospital Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations