deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT02051218

Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks

Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks - A Non-Inferiority Phase III Trial

Sponsor: Swiss Cancer Institute

Conditions Bone Metastases Metastatic Breast Cancer Metastatic Prostate Cancer
Interventions Denosumab (reduced dosing) Denosumab (standard dosing)
Updated 37 times since 2017 Last updated: Dec 23, 2025 Started: Jul 16, 2014 Primary completion: Jun 30, 2026 Completion: Dec 31, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Bone Metastases and Metastatic Breast Cancer, this trial is ongoing. The trial is conducted by Swiss Cancer Institute and has accumulated 37 data snapshots since 2014. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Dec 2017 · 11 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Mar 2019 · 3 months · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Feb 2020 · 3 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Oct 2020 · 5 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Sep 2021 · 7 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Apr 2024 · 10 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshot~Apr 2025 – ~Aug 2025 · 4 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Jan 2026 · 4 months · monthly snapshot~Jan 2026 – present · 6 months · monthly snapshot

Change History

37 versions recorded

  1. Jan 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Sep 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Apr 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Sep 2024 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

▶ Show 32 earlier versions

  1. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  2. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE3

  3. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  4. Jun 2023 — Apr 2024 [monthly]

    Recruiting PHASE3

  5. Apr 2023 — Jun 2023 [monthly]

    Recruiting PHASE3

  6. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE3

  7. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE3

  8. Sep 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  9. May 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  10. Feb 2022 — May 2022 [monthly]

    Recruiting PHASE3

  11. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

    Status: Active Not Recruiting → Recruiting

  12. Nov 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE3

  13. Sep 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE3

  14. Feb 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  15. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  16. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  17. May 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  18. Mar 2020 — May 2020 [monthly]

    Recruiting PHASE3

  19. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  20. Nov 2019 — Feb 2020 [monthly]

    Recruiting PHASE3

  21. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  22. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  23. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  24. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  25. Apr 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  26. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  27. Dec 2018 — Mar 2019 [monthly]

    Recruiting PHASE3

  28. Oct 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  29. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  30. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  31. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE3

  32. Jan 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

    First recorded

Jul 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Swiss Cancer Institute
Data source: Swiss Cancer Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aarau, Switzerland , Baden, Switzerland , Basel, Switzerland , Bellinzona, Switzerland , Bern, Switzerland , Biel, Switzerland , Brig, Switzerland , Chur, Switzerland , Chêne-Bougeries, Switzerland , Düsseldorf, Germany and 26 more locations