deltatrials
Terminated PHASE3 INTERVENTIONAL 2-arm NCT00004935

Herceptin Followed by Chemotherapy in Treating Women With Metastatic Breast Cancer That Overexpresses HER2

Randomized Phase III Trial of Herceptin® Followed by Chemotherapy Plus Herceptin® Versus the Combination of Herceptin® and Chemotherapy as Palliative Treatment in Patients With HER2- Overexpressing Advanced/Metastatic Breast Cancer.

Sponsor: Swiss Cancer Institute

Conditions Breast Cancer
Updated 15 times since 2017 Last updated: Apr 12, 2023 Started: Aug 30, 1999 Primary completion: Nov 6, 2014 Completion: Mar 31, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Trial is Life long follow-up: to reduce ressources and costs - trial terminated prematurely.

This PHASE3 trial investigates Breast Cancer and is currently terminated or withdrawn. Swiss Cancer Institute leads this study, which shows 15 recorded versions since 1999 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Dec 2017 · 11 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Apr 2019 · 8 months · monthly snapshot~Apr 2019 – ~Feb 2020 · 10 months · monthly snapshot~Feb 2020 – ~Jan 2021 · 11 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Oct 2021 · 7 months · monthly snapshot~Oct 2021 – ~Apr 2022 · 6 months · monthly snapshot~Apr 2022 – ~May 2023 · 13 months · monthly snapshot~May 2023 – ~Jul 2024 · 14 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Aug 2025 · 11 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – present · 9 months · monthly snapshot

Change History

15 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Aug 2025 — Sep 2025 [monthly]

    Terminated PHASE3

  3. Sep 2024 — Aug 2025 [monthly]

    Terminated PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE3

  5. May 2023 — Jul 2024 [monthly]

    Terminated PHASE3

    Status: Active Not RecruitingTerminated

Show 10 earlier versions
  1. Apr 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  2. Oct 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  3. Mar 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE3

  4. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE3

  5. Feb 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  6. Apr 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  7. Aug 2018 — Apr 2019 [monthly]

    Active Not Recruiting PHASE3

  8. Jun 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE3

  9. Dec 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  10. Jan 2017 — Dec 2017 [monthly]

    Active Not Recruiting PHASE3

    First recorded

Aug 1999

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Swiss Cancer Institute
Data source: Swiss Cancer Institute

For direct contact, visit the study record on ClinicalTrials.gov .