deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT02125461

A Global Study to Assess the Effects of MEDI4736 Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer (PACIFIC)

A Phase III, Randomised, Double-blind, Placebo-controlled, Multi-centre, International Study of MEDI4736 as Sequential Therapy in Patients With Locally Advanced, Unresectable Non-Small Cell Lung Cancer (Stage III) Who Have Not Progressed Following Definitive, Platinum-based, Concurrent Chemoradiation Therapy (PACIFIC)

Sponsor: AstraZeneca

Interventions MEDI4736 PLACEBO
Updated 30 times since 2017 Last updated: Sep 21, 2023 Started: May 7, 2014 Primary completion: Feb 13, 2017 Completion: Aug 24, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Non-Small Cell Lung Cancer and is currently completed. AstraZeneca leads this study, which shows 30 recorded versions since 2014 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Jun 2017 · 3 months · monthly snapshot~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Feb 2018 · 7 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Feb 2019 · 8 months · monthly snapshot~Feb 2019 – ~May 2019 · 3 months · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Jan 2020 · 3 months · monthly snapshot~Jan 2020 – ~Apr 2020 · 3 months · monthly snapshot~Apr 2020 – ~Oct 2020 · 6 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~May 2023 · 3 months · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Nov 2023 · 3 months · monthly snapshot~Nov 2023 – ~Jul 2024 · 8 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 9 months · monthly snapshot

Change History

30 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Nov 2023 — Jul 2024 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  5. Aug 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

Show 25 earlier versions
  1. May 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  2. Feb 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  3. Dec 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  4. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

  5. May 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  6. Feb 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE3

  7. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  8. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE3

  9. Oct 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE3

  10. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE3

  11. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  12. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  13. Apr 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE3

  14. Jan 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  15. Oct 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

  16. Jul 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE3

  17. May 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE3

  18. Feb 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE3

  19. Jun 2018 — Feb 2019 [monthly]

    Active Not Recruiting PHASE3

  20. Feb 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  21. Jul 2017 — Feb 2018 [monthly]

    Active Not Recruiting PHASE3

  22. Jun 2017 — Jul 2017 [monthly]

    Active Not Recruiting PHASE3

  23. Mar 2017 — Jun 2017 [monthly]

    Active Not Recruiting PHASE3

  24. Feb 2017 — Mar 2017 [monthly]

    Active Not Recruiting PHASE3

  25. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE3

    First recorded

May 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
Data source: AstraZeneca

For direct contact, visit the study record on ClinicalTrials.gov .