Completed PHASE3 INTERVENTIONAL 4-arm NCT02162563

Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases (CAIRO5)

Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases CAIRO5 a Randomized Phase 3 Study of the Dutch Colorectal Cancer Group (DCCG)

Sponsor: Dutch Colorectal Cancer Group

Conditions Colorectal Cancer Liver Metastases

Interventions FOLFOX/ FOLFIRI with bevacizumab FOLFOX/ FOLFIRI with panitumumab FOLFOXIRI with bevacizumab

Updated 13 times since 2017 Last updated: Feb 4, 2025 Started: Jul 31, 2014 Primary completion: Jul 31, 2022 Completion: Jan 31, 2025

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Colorectal Cancer and Liver Metastases, this trial is completed. The trial is conducted by Dutch Colorectal Cancer Group and has accumulated 13 data snapshots since 2014. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

13 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Jun 2025 — Sep 2025 [monthly]

Completed PHASE3
Mar 2025 — Jun 2025 [monthly]

Completed PHASE3

Status: Recruiting → Completed
Sep 2024 — Mar 2025 [monthly]

Recruiting PHASE3
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE3

▶ Show 8 earlier versions

Apr 2022 — Jul 2024 [monthly]

Recruiting PHASE3
Dec 2021 — Apr 2022 [monthly]

Recruiting PHASE3
Oct 2021 — Dec 2021 [monthly]

Recruiting PHASE3
Jan 2021 — Oct 2021 [monthly]

Recruiting PHASE3
Mar 2019 — Jan 2021 [monthly]

Recruiting PHASE3
Jun 2018 — Mar 2019 [monthly]

Recruiting PHASE3
Oct 2017 — Jun 2018 [monthly]

Recruiting PHASE3
Jan 2017 — Oct 2017 [monthly]

Recruiting PHASE3

First recorded

Jul 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Dutch Colorectal Cancer Group

Data source: Dutch Colorectal Cancer Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

's-Hertogenbosch, Netherlands , Alkmaar, Netherlands , Almere Stad, Netherlands , Amersfoort, Netherlands , Amsterdam, Netherlands , Antwerp, Belgium , Apeldoorn, Netherlands , Arnhem, Netherlands , Bergen op Zoom, Netherlands , Breda, Netherlands and 35 more locations