Completed PHASE2 INTERVENTIONAL 3-arm NCT02208037

Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)

A Multi-center Phase II Trial Randomizing Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN #1203; Progress I)

Sponsor: Blood and Marrow Transplant Clinical Trials Network

Conditions Acute Leukemia Chronic Lymphocytic Leukemia Chronic Myelogenous Leukemia Hodgkin's Lymphoma Lymphoma, B-Cell Lymphoma, Follicular Lymphoma, Large B-Cell, Diffuse Myelodysplasia Small Lymphocytic Lymphoma

Interventions Bortezomib Cyclophosphamide Maraviroc Methotrexate (ARM with Bortezomib) Methotrexate (ARM with Maraviroc) Mycophenolate mofetil Tacrolimus (ARM with MMF and Cyclophosphamide) Tacrolimus (ARM with Methotrexate)

Updated 12 times since 2017 Last updated: Jan 2, 2019 Started: Aug 31, 2014 Primary completion: Oct 31, 2017 Completion: Oct 31, 2017

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Acute Leukemia and Chronic Lymphocytic Leukemia, this trial is completed. The trial is conducted by Blood and Marrow Transplant Clinical Trials Network and has accumulated 12 data snapshots since 2014. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

12 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2
Jan 2023 — Jul 2024 [monthly]

Completed PHASE2
Dec 2022 — Jan 2023 [monthly]

Completed PHASE2

▶ Show 7 earlier versions

Jan 2021 — Dec 2022 [monthly]

Completed PHASE2
Feb 2019 — Jan 2021 [monthly]

Completed PHASE2
Jun 2018 — Feb 2019 [monthly]

Completed PHASE2
May 2018 — Jun 2018 [monthly]

Completed PHASE2

Status: Active Not Recruiting → Completed
Apr 2018 — May 2018 [monthly]

Active Not Recruiting PHASE2
Feb 2017 — Apr 2018 [monthly]

Active Not Recruiting PHASE2
Jan 2017 — Feb 2017 [monthly]

Active Not Recruiting PHASE2

First recorded

Aug 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Blood and Marrow Transplant Clinical Trials Network
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)

Data source: National Heart, Lung, and Blood Institute (NHLBI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Baltimore, United States , Boston, United States , Buffalo, United States , Chapel Hill, United States , Charleston, United States , Cleveland, United States , Columbus, United States , Detroit, United States , Duarte, United States and 17 more locations