deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT02275533

Testing Nivolumab to Prevent Disease From Coming Back After Treatment in Patients With Acute Myeloid Leukemia, REMAIN Trial

Randomized Phase II Study to Assess the Role of Nivolumab as Single Agent to Eliminate Minimal Residual Disease and Maintain Remission in Acute Myelogenous Leukemia (AML) Patients After Chemotherapy (REMAIN TRIAL)

Sponsor: National Cancer Institute (NCI)

Conditions Acute Myeloid Leukemia
Interventions Biospecimen Collection Bone Marrow Biopsy Clinical Observation Echocardiography Test Nivolumab
Updated 63 times since 2017 Last updated: Mar 12, 2026 Started: Jul 2, 2015 Primary completion: Jul 28, 2025 Completion: Oct 8, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Acute Myeloid Leukemia and is currently ongoing. National Cancer Institute (NCI) leads this study, which shows 63 recorded versions since 2015 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Feb 2018 · 2 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Aug 2020 · 6 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~May 2021 · 3 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Apr 2022 · 6 months · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jul 2023 · 3 months · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Feb 2024 · 4 months · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Dec 2024 · 2 months · monthly snapshot~Dec 2024 – ~May 2025 · 5 months · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Aug 2025 · 2 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Mar 2026 · 59 days · monthly snapshot~Mar 2026 – present · 4 months · monthly snapshot

Change History

63 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Jan 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE2

  4. Nov 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 58 earlier versions

  1. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  2. Jun 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE2

  3. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Dec 2024 — May 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Oct 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2

  7. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  8. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  9. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  10. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

  11. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  12. Oct 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE2

  13. Aug 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

  14. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE2

  15. Apr 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE2

  16. Feb 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE2

  17. Sep 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

  18. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  19. May 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

  20. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE2

  21. Oct 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

  22. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE2

  23. May 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  24. Feb 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE2

  25. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE2

  26. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  27. Aug 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

  28. Feb 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE2

  29. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  30. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  31. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  32. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  33. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  34. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  35. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  36. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  37. May 2019 — Jun 2019 [monthly]

    Suspended PHASE2

  38. Apr 2019 — May 2019 [monthly]

    Suspended PHASE2

  39. Mar 2019 — Apr 2019 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  40. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  41. Dec 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  42. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  43. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  44. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  45. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  46. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  47. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  48. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  49. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE2

  50. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE2

  51. Dec 2017 — Feb 2018 [monthly]

    Recruiting PHASE2

  52. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  53. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  54. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE2

  55. Jun 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  56. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  57. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE2

  58. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Jul 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Baltimore, United States , Bethesda, United States , Birmingham, United States , Buffalo, United States , Chicago, United States , Cleveland, United States , Dallas, United States , Decatur, United States , Detroit, United States , Duarte, United States and 28 more locations