A Study Evaluating the Safety of Tocilizumab in Addition to Standard of Care Premedication Given Before Obinutuzumab + Chlorambucil in Participants With Untreated B-Cell Chronic Lymphocytic Leukemia (B-CLL) and Comorbidities
A Multicenter, Double-Blind, Randomized, and Placebo-controlled Phase Ib Study Evaluating the Safety of Adding Tocilizumab to Standard Premedications Prior to Administration of Obinutuzumab in Combination With Chlorambucil in Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia and Comorbidities
Sponsor: Hoffmann-La Roche
Terminated
This study was terminated early because premedication with tocilizumab was unlikely to reduce the risk of IRR.
Other terminated trials from Hoffmann-La Roche
Other B-Cell Chronic Lymphocytic Leukemia trials with similar outcome
Listed as NCT02336048, this PHASE1 trial focuses on B-Cell Chronic Lymphocytic Leukemia and remains terminated or withdrawn. Sponsored by Hoffmann-La Roche, it has been updated 15 times since 2015, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.
Status Flow
Change History
15 versions recorded-
Sep 2025 — Present [monthly]
Terminated PHASE1
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Sep 2024 — Sep 2025 [monthly]
Terminated PHASE1
-
Jul 2024 — Sep 2024 [monthly]
Terminated PHASE1
-
Dec 2021 — Jul 2024 [monthly]
Terminated PHASE1
-
May 2021 — Dec 2021 [monthly]
Terminated PHASE1
Status: Completed → Terminated
▶ Show 10 earlier versions
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Jan 2021 — May 2021 [monthly]
Completed PHASE1
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Oct 2020 — Jan 2021 [monthly]
Completed PHASE1
Status: Terminated → Completed
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Nov 2019 — Oct 2020 [monthly]
Terminated PHASE1
Status: Completed → Terminated
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Nov 2018 — Nov 2019 [monthly]
Completed PHASE1
Status: Active Not Recruiting → Completed
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Aug 2018 — Nov 2018 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
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Jul 2018 — Aug 2018 [monthly]
Recruiting PHASE1
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Jun 2018 — Jul 2018 [monthly]
Recruiting PHASE1
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Apr 2017 — Jun 2018 [monthly]
Recruiting PHASE1
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Feb 2017 — Apr 2017 [monthly]
Recruiting PHASE1
-
Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE1
First recorded
Jun 2015
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Hoffmann-La Roche
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Barcelona, Spain , Cagliari, Italy , Genoa, Italy , Haifa, Israel , Kfar Saba, Israel , London, United Kingdom , Madrid, Spain , Milan, Italy , Rehovot, Israel , Riga, Latvia and 3 more locations