deltatrials
Active Not Recruiting NA INTERVENTIONAL 2-arm NCT02338947

Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients (FRAGILE)

A Multicenter, Prospective, Randomized, Clinical Trial Comparing Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients

Sponsor: Beneficência Portuguesa de São Paulo

Conditions Coronary Artery Disease Frail Elderly
Interventions Off-pump coronary-artery bypass grafting On-pump coronary-artery bypass grafting
Updated 14 times since 2017 Last updated: Feb 27, 2025 Started: Jan 1, 2019 Primary completion: Dec 31, 2024 Completion: Dec 31, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates Coronary Artery Disease and Frail Elderly and is currently ongoing. Beneficência Portuguesa de São Paulo leads this study, which shows 14 recorded versions since 2019 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

~Jan 2017 – ~Nov 2017 · 10 months · monthly snapshot~Nov 2017 – ~Jun 2018 · 7 months · monthly snapshot~Jun 2018 – ~Nov 2018 · 5 months · monthly snapshot~Nov 2018 – ~Jul 2019 · 8 months · monthly snapshot~Jul 2019 – ~Dec 2019 · 5 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Mar 2023 · 24 months · monthly snapshot~Mar 2023 – ~Jul 2024 · 16 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshot~Apr 2025 – ~Sep 2025 · 5 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

14 versions recorded

  1. Sep 2025 — Present [monthly]

    Active Not Recruiting NA

  2. Apr 2025 — Sep 2025 [monthly]

    Active Not Recruiting NA

    Status: Unknown → Active Not Recruiting

  3. Sep 2024 — Apr 2025 [monthly]

    Unknown NA

  4. Jul 2024 — Sep 2024 [monthly]

    Unknown NA

    Status: Unknown Status → Unknown

  5. Mar 2023 — Jul 2024 [monthly]

    Unknown Status NA

    Status: Recruiting → Unknown Status

▶ Show 9 earlier versions

  1. Mar 2021 — Mar 2023 [monthly]

    Recruiting NA

  2. Jan 2021 — Mar 2021 [monthly]

    Recruiting NA

  3. Jan 2020 — Jan 2021 [monthly]

    Recruiting NA

  4. Dec 2019 — Jan 2020 [monthly]

    Recruiting NA

  5. Jul 2019 — Dec 2019 [monthly]

    Recruiting NA

    Status: Not Yet Recruiting → Recruiting

  6. Nov 2018 — Jul 2019 [monthly]

    Not Yet Recruiting NA

  7. Jun 2018 — Nov 2018 [monthly]

    Not Yet Recruiting NA

  8. Nov 2017 — Jun 2018 [monthly]

    Not Yet Recruiting NA

  9. Jan 2017 — Nov 2017 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Beneficência Portuguesa de São Paulo
  • Clinical Hospital Samuel Libânio of Pouso Alegre
  • Hospital do Coração de Messejana Dr. Carlos Alberto Studart
  • Instituto Nacional de Cardiologia de Laranjeiras
  • University of Sao Paulo General Hospital
Data source: University of Sao Paulo General Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations