Study of MEN1112 Intravenous Infusion in Relapsed or Refractory Acute Myeloid Leukemia (ARMY)
First in Man Study With MEN1112, a CD157 Targeted Monoclonal Antibody, in Relapsed or Refractory Acute Myeloid Leukemia.
Sponsor: Menarini Group
Terminated
The Sponsor accepted the iDSMB recommendation to terminate the study due to evidence of unpredictable liver toxicity and meaningful target engagement not translating into any clinical objective response.
Other terminated trials from Menarini Group
- Surgical Site Infection · Phase PHASE3 · Oct 2020
- Metastatic Solid Tumors · Phase PHASE1 · Jan 2020
- Tumor Lysis Syndrome · Phase PHASE1/PHASE2 · Jul 2018
- Irritable Bowel Syndrome With Diarrhea · Phase PHASE3 · Nov 2015
- Ovarian Cancer · Phase PHASE2/PHASE3 · Jun 2011
More terminations from Menarini Group
This PHASE1 trial investigates Acute Myeloid Leukemia, in Relapse and Recurrent Adult Acute Myeloid Leukemia and is currently terminated or withdrawn. Menarini Group leads this study, which shows 18 recorded versions since 2014 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.
Status Flow
Change History
18 versions recorded-
Sep 2025 — Present [monthly]
Terminated PHASE1
-
Sep 2024 — Sep 2025 [monthly]
Terminated PHASE1
-
Jul 2024 — Sep 2024 [monthly]
Terminated PHASE1
-
Dec 2021 — Jul 2024 [monthly]
Terminated PHASE1
-
Sep 2021 — Dec 2021 [monthly]
Terminated PHASE1
Status: Active Not Recruiting → Terminated
▶ Show 13 earlier versions
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Jun 2021 — Sep 2021 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
-
Mar 2021 — Jun 2021 [monthly]
Recruiting PHASE1
Status: Unknown Status → Recruiting
-
Jan 2021 — Mar 2021 [monthly]
Unknown Status PHASE1
-
Nov 2020 — Jan 2021 [monthly]
Unknown Status PHASE1
Status: Recruiting → Unknown Status
-
Feb 2019 — Nov 2020 [monthly]
Recruiting PHASE1
-
Nov 2018 — Feb 2019 [monthly]
Recruiting PHASE1
Status: Active Not Recruiting → Recruiting
-
Sep 2018 — Nov 2018 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
-
Aug 2018 — Sep 2018 [monthly]
Recruiting PHASE1
-
Jun 2018 — Aug 2018 [monthly]
Recruiting PHASE1
-
Jul 2017 — Jun 2018 [monthly]
Recruiting PHASE1
-
May 2017 — Jul 2017 [monthly]
Recruiting PHASE1
-
Feb 2017 — May 2017 [monthly]
Recruiting PHASE1
-
Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE1
First recorded
Dec 2014
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Menarini Group
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Antwerp, Belgium , Badalona, Spain , Barcelona, Spain , Bologna, Italy , Brescia, Italy , Brussels, Belgium , Dresden, Germany , Essen, Germany , Frankfurt, Germany , Grenoble, France and 19 more locations