deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT02367781

A Study of Atezolizumab in Combination With Carboplatin Plus (+) Nab-Paclitaxel Compared With Carboplatin+Nab-Paclitaxel in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower130)

A Phase III Multicenter, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Atezolizumab (MPDL3280A, Anti-PD-L1 Antibody) in Combination With Carboplatin+Nab-Paclitaxel for Chemotherapy-Naive Patients With Stage IV Non-Squamous Non-Small Cell Lung Cancer

Sponsor: Hoffmann-La Roche

Conditions Carcinoma, Non-Squamous Non-Small Cell Lung
Interventions Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody Carboplatin Nab-Paclitaxel Pemetrexed
Updated 23 times since 2017 Last updated: Jul 15, 2021 Started: Apr 16, 2015 Primary completion: Mar 15, 2018 Completion: Jan 18, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Carcinoma, Non-Squamous Non-Small Cell Lung, this trial is completed. The trial is conducted by Hoffmann-La Roche and has accumulated 23 data snapshots since 2015. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Oct 2017 · 5 months · monthly snapshot~Oct 2017 – ~Jan 2018 · 3 months · monthly snapshot~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Oct 2018 · 3 months · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Mar 2019 · 3 months · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Nov 2019 · 3 months · monthly snapshot~Nov 2019 – ~Feb 2020 · 3 months · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Jul 2024 · 34 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

23 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Sep 2021 — Jul 2024 [monthly]

    Completed PHASE3

  5. Jan 2021 — Sep 2021 [monthly]

    Completed PHASE3

▶ Show 18 earlier versions

  1. Sep 2020 — Jan 2021 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  2. Jul 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

  3. May 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  4. Feb 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  5. Nov 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  6. Aug 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE3

  7. Jun 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE3

  8. May 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE3

  9. Mar 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE3

  10. Dec 2018 — Mar 2019 [monthly]

    Active Not Recruiting PHASE3

  11. Oct 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE3

  12. Jul 2018 — Oct 2018 [monthly]

    Active Not Recruiting PHASE3

  13. Jun 2018 — Jul 2018 [monthly]

    Active Not Recruiting PHASE3

  14. Jan 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  15. Oct 2017 — Jan 2018 [monthly]

    Active Not Recruiting PHASE3

  16. May 2017 — Oct 2017 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  17. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE3

  18. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Apr 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

A Coruña, Spain , Athens, United States , Avellino, Italy , Barcelona, Spain , Barrie, Canada , Beer Yaakov, Israel , Beersheba, Israel , Berlin, Germany , Bethesda, United States , Bordeaux, France and 118 more locations