Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer
Regorafenib Dose Optimization Study (ReDOS): A Phase II Randomized Study of Lower Dose Regorafenib Compared to Standard Dose Regorafenib in Patients With Refractory Metastatic Colorectal Cancer (mCRC)
Sponsor: Academic and Community Cancer Research United
Listed as NCT02368886, this PHASE2 trial focuses on Colon Adenocarcinoma and Rectal Adenocarcinoma and remains completed. Sponsored by Academic and Community Cancer Research United, it has been updated 29 times since 2015, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.
Change History
29 versions recorded-
Sep 2025 — Present [monthly]
Completed PHASE2
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Jul 2025 — Sep 2025 [monthly]
Completed PHASE2
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Sep 2024 — Jul 2025 [monthly]
Completed PHASE2
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Jul 2024 — Sep 2024 [monthly]
Completed PHASE2
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Aug 2023 — Jul 2024 [monthly]
Completed PHASE2
▶ Show 24 earlier versions
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Apr 2023 — Aug 2023 [monthly]
Completed PHASE2
Status: Active Not Recruiting → Completed
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Mar 2023 — Apr 2023 [monthly]
Active Not Recruiting PHASE2
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Feb 2022 — Mar 2023 [monthly]
Active Not Recruiting PHASE2
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Oct 2021 — Feb 2022 [monthly]
Active Not Recruiting PHASE2
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Sep 2021 — Oct 2021 [monthly]
Active Not Recruiting PHASE2
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Apr 2021 — Sep 2021 [monthly]
Active Not Recruiting PHASE2
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Jan 2021 — Apr 2021 [monthly]
Active Not Recruiting PHASE2
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Oct 2020 — Jan 2021 [monthly]
Active Not Recruiting PHASE2
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Aug 2020 — Oct 2020 [monthly]
Active Not Recruiting PHASE2
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Jun 2020 — Aug 2020 [monthly]
Active Not Recruiting PHASE2
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Feb 2020 — Jun 2020 [monthly]
Active Not Recruiting PHASE2
Status: Completed → Active Not Recruiting
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Jan 2020 — Feb 2020 [monthly]
Completed PHASE2
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Dec 2019 — Jan 2020 [monthly]
Completed PHASE2
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Aug 2019 — Dec 2019 [monthly]
Completed PHASE2
Status: Active Not Recruiting → Completed
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Jun 2019 — Aug 2019 [monthly]
Active Not Recruiting PHASE2
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May 2019 — Jun 2019 [monthly]
Active Not Recruiting PHASE2
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Mar 2019 — May 2019 [monthly]
Active Not Recruiting PHASE2
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Sep 2018 — Mar 2019 [monthly]
Active Not Recruiting PHASE2
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Jun 2018 — Sep 2018 [monthly]
Active Not Recruiting PHASE2
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Mar 2018 — Jun 2018 [monthly]
Active Not Recruiting PHASE2
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Aug 2017 — Mar 2018 [monthly]
Active Not Recruiting PHASE2
Status: Recruiting → Active Not Recruiting
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May 2017 — Aug 2017 [monthly]
Recruiting PHASE2
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Feb 2017 — May 2017 [monthly]
Recruiting PHASE2
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Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE2
First recorded
Mar 2015
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Academic and Community Cancer Research United
- National Cancer Institute (NCI)
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Boston, United States, Buffalo, United States, Columbus, United States, Danville, United States, East Syracuse, United States, Green Bay, United States, Kingsport, United States, Los Angeles, United States, Marshfield, United States, Omaha, United States and 11 more location s