deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT02390843

Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors (AflacST1402)

A Phase 1 Study Using Simvastatin in Combination With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors

Sponsor: Children's Healthcare of Atlanta

Conditions Clear Cell Sarcoma Ewings Sarcoma Germ Cell Tumors Hepatoblastoma Neuroblastoma Non-rhabdomyosarcoma Soft Tissue Sarcoma Osteosarcoma Renal Cell Carcinoma Retinoblastoma Rhabdoid Tumor Rhabdomyosarcoma Wilms Tumor
Interventions Cyclophosphamide Myeloid growth factor Simvastatin Topotecan
Updated 9 times since 2017 Last updated: Apr 1, 2020 Started: Feb 28, 2015 Primary completion: Sep 22, 2019 Completion: Sep 22, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02390843, this PHASE1 trial focuses on Clear Cell Sarcoma and Ewings Sarcoma and remains completed. Sponsored by Children's Healthcare of Atlanta, it has been updated 9 times since 2015, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotRecruiting~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshotRecruiting~Jun 2018 – ~Jul 2019 · 13 months · monthly snapshotRecruiting~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshotRecruiting~Sep 2019 – ~May 2020 · 8 months · monthly snapshotRecruiting~May 2020 – ~Jan 2021 · 8 months · monthly snapshotCompleted~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – present · 24 months · monthly snapshotCompleted

Change History

9 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE1

  4. May 2020 — Jan 2021 [monthly]

    Completed PHASE1

    Status: Recruiting → Completed

  5. Sep 2019 — May 2020 [monthly]

    Recruiting PHASE1

▶ Show 4 earlier versions

  1. Jul 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  2. Jun 2018 — Jul 2019 [monthly]

    Recruiting PHASE1

  3. Feb 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

  4. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Feb 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Children's Healthcare of Atlanta
  • Emory University
Data source: Emory University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations