deltatrials
Completed PHASE1 INTERVENTIONAL 2-arm NCT02402920

Pembrolizumab and Concurrent Chemoradiotherapy or Radiation Therapy in Treating Patients With Small Cell Lung Cancer

Phase I Trial of MK-3475 and Concurrent Chemo/Radiation for the Elimination of Small Cell Lung Cancer

Sponsor: M.D. Anderson Cancer Center

Conditions Extensive Stage Small Cell Lung Carcinoma Limited Stage Small Cell Lung Carcinoma Neuroendocrine Neoplasm
Interventions Carboplatin Cisplatin Etoposide Laboratory Biomarker Analysis Pembrolizumab Radiation Therapy
Updated 17 times since 2017 Last updated: Feb 19, 2026 Started: Jul 22, 2015 Primary completion: Dec 23, 2025 Completion: Feb 9, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Extensive Stage Small Cell Lung Carcinoma and Limited Stage Small Cell Lung Carcinoma, this trial is completed. The trial is conducted by M.D. Anderson Cancer Center and has accumulated 17 data snapshots since 2015. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2018 · 13 months · monthly snapshot~Jun 2018 – ~Dec 2018 · 6 months · monthly snapshot~Dec 2018 – ~Jan 2020 · 13 months · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Mar 2022 · 6 months · monthly snapshot~Mar 2022 – ~Nov 2023 · 20 months · monthly snapshot~Nov 2023 – ~Jun 2024 · 7 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Jun 2025 · 6 months · monthly snapshot~Jun 2025 – ~Nov 2025 · 5 months · monthly snapshot~Nov 2025 – ~Mar 2026 · 4 months · monthly snapshot~Mar 2026 – present · 4 months · monthly snapshot

Change History

17 versions recorded

  1. Mar 2026 — Present [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Nov 2025 — Mar 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Jun 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Dec 2024 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 12 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Nov 2023 — Jun 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Mar 2022 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  5. Sep 2021 — Mar 2022 [monthly]

    Recruiting PHASE1

  6. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  7. Jan 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  8. Dec 2018 — Jan 2020 [monthly]

    Recruiting PHASE1

  9. Jun 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  10. May 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

  11. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE1

  12. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Jul 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations