deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT02466971

Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers

A Randomized Phase III Trial of Radiation Therapy and Cisplatin Alone or in Combination With Intravenous Triapine in Women With Newly Diagnosed Bulky Stage IB2, Stage II, IIIB, or IVA Cancer of the Uterine Cervix or Stage II-IVA Vaginal Cancer

Sponsor: NRG Oncology

Conditions Advanced Vaginal Adenocarcinoma Advanced Vaginal Adenosquamous Carcinoma Advanced Vaginal Squamous Cell Carcinoma Cervical Adenocarcinoma Cervical Adenosquamous Carcinoma Cervical Squamous Cell Carcinoma Stage IB2 Cervical Cancer AJCC v6 and v7 Stage II Cervical Cancer AJCC v7 Stage II Vaginal Cancer AJCC v6 and v7 Stage IIA Cervical Cancer AJCC v7 Stage IIB Cervical Cancer AJCC v6 and v7 Stage III Vaginal Cancer AJCC v6 and v7 Stage IIIB Cervical Cancer AJCC v6 and v7 Stage IV Vaginal Cancer AJCC v6 and v7 Stage IVA Cervical Cancer AJCC v6 and v7 Stage IVA Vaginal Cancer AJCC v6 and v7 Unresectable Vaginal Carcinoma Vaginal Adenocarcinoma Vaginal Adenosquamous Carcinoma Vaginal Carcinoma Vaginal Squamous Cell Carcinoma, Not Otherwise Specified
Interventions Brachytherapy Cisplatin External Beam Radiation Therapy Intensity-Modulated Radiation Therapy Laboratory Biomarker Analysis Radiation Therapy Triapine
Updated 81 times since 2017 Last updated: Mar 12, 2026 Started: May 10, 2016 Primary completion: Jan 26, 2023 Completion: Jul 14, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02466971, this PHASE3 trial focuses on Advanced Vaginal Adenocarcinoma and Advanced Vaginal Adenosquamous Carcinoma and remains ongoing. Sponsored by NRG Oncology, it has been updated 81 times since 2016, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Oct 2017 · 2 months · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~May 2019 · 6 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Feb 2023 · 3 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Sep 2023 · 2 months · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Feb 2024 · 4 months · monthly snapshot~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~Jun 2024 · 2 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Jan 2025 · 3 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~Aug 2025 · 4 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Jan 2026 · 2 months · monthly snapshot~Jan 2026 – ~Mar 2026 · 59 days · monthly snapshot~Mar 2026 – present · 6 months · monthly snapshot

Change History

81 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Jan 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Nov 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

  4. Sep 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

▶ Show 76 earlier versions

  1. Apr 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Oct 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

  6. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  7. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  9. Apr 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

  10. Feb 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE3

  11. Oct 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  12. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  13. Jul 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  14. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  15. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  16. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  17. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  18. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  19. Nov 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  20. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  21. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  22. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  23. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  24. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

  25. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  26. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  27. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  28. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  29. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  30. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

    Status: Suspended → Recruiting

  31. Sep 2021 — Oct 2021 [monthly]

    Suspended PHASE3

    Status: Recruiting → Suspended

  32. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  33. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  34. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE3

  35. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  36. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  37. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  38. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  39. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  40. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  41. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  42. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  43. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  44. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  45. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  46. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE3

  47. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE3

  48. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  49. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE3

  50. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

  51. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE3

  52. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  53. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  54. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  55. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  56. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  57. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

    Phase: PHASE2 → PHASE3

  58. Nov 2018 — May 2019 [monthly]

    Recruiting PHASE2

  59. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  60. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  61. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  62. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  63. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  64. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  65. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE2

  66. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  67. Jan 2018 — Feb 2018 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  68. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE2

  69. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  70. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  71. Aug 2017 — Oct 2017 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  72. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  73. Jun 2017 — Jul 2017 [monthly]

    Recruiting PHASE2

  74. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  75. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE2

  76. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

May 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • NRG Oncology
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aberdeen, United States , Abington, United States , Akron, United States , Albany, United States , Albuquerque, United States , Anchorage, United States , Antioch, United States , Atlanta, United States , Auburn, United States , Augusta, United States and 240 more locations