deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT02499120

Safety And Efficacy Study Of Palbociclib Plus Cetuximab Versus Cetuximab To Treat Head And Neck Cancer

A RANDOMIZED, MULTICENTER, DOUBLE-BLIND PHASE 2 STUDY OF PALBOCICLIB PLUS CETUXIMAB VERSUS CETUXIMAB FOR THE TREATMENT OF HUMAN PAPILLOMAVIRUS-NEGATIVE, CETUXIMAB-NAÏVE PATIENTS WITH RECURRENT/METASTATIC SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK AFTER FAILURE OF ONE PRIOR PLATINUM-CONTAINING CHEMOTHERAPY REGIMEN

Sponsor: Pfizer

Updated 33 times since 2017 Last updated: Aug 14, 2023 Started: Sep 10, 2015 Primary completion: Jul 19, 2018 Completion: Sep 7, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Squamous Cell Carcinoma of the Head and Neck (SCCHN) and is currently completed. Pfizer leads this study, which shows 33 recorded versions since 2015 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~Jun 2017 · 2 months · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Oct 2017 · 2 months · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Feb 2018 · 2 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Oct 2019 · 4 months · monthly snapshot~Oct 2019 – ~Jan 2021 · 15 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Sep 2022 · 9 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Oct 2023 · 11 months · monthly snapshot~Oct 2023 – ~Jul 2024 · 9 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

33 versions recorded
  1. Dec 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE2

  3. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  5. Oct 2023 — Jul 2024 [monthly]

    Completed PHASE2

Show 28 earlier versions
  1. Nov 2022 — Oct 2023 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  2. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: Unknown StatusActive Not Recruiting

  3. Dec 2021 — Sep 2022 [monthly]

    Unknown Status PHASE2

  4. Oct 2021 — Dec 2021 [monthly]

    Unknown Status PHASE2

    Status: Active Not RecruitingUnknown Status

  5. Jan 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE2

  6. Oct 2019 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  7. Jun 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE2

  8. May 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE2

  9. Apr 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE2

  10. Mar 2019 — Apr 2019 [monthly]

    Active Not Recruiting PHASE2

  11. Jan 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE2

  12. Dec 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE2

  13. Nov 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE2

  14. Sep 2018 — Nov 2018 [monthly]

    Active Not Recruiting PHASE2

  15. Aug 2018 — Sep 2018 [monthly]

    Active Not Recruiting PHASE2

  16. Jul 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE2

  17. Jun 2018 — Jul 2018 [monthly]

    Active Not Recruiting PHASE2

  18. Apr 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE2

  19. Mar 2018 — Apr 2018 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  20. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE2

  21. Dec 2017 — Feb 2018 [monthly]

    Recruiting PHASE2

  22. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  23. Aug 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  24. Jun 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  25. Apr 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  26. Mar 2017 — Apr 2017 [monthly]

    Recruiting PHASE2

  27. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE2

  28. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Sep 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Pfizer
Data source: Pfizer

For direct contact, visit the study record on ClinicalTrials.gov .