deltatrials
Completed PHASE2 INTERVENTIONAL 3-arm NCT02523313

Immunotherapy With Nivolumab or Nivolumab Plus Ipilimumab vs. Double Placebo for Stage IV Melanoma w. NED

A Phase II Randomized, Double-Blind Trial of Immunotherapy With Nivolumab or Nivolumab Plus Ipilimumab Versus Double-Placebo Control as a Post-Surgical/Post-Radiation Treatment for Stage IV Melanoma With No Evidence of Disease

Sponsor: Prof. Dr. med. Dirk Schadendorf

Updated 11 times since 2017 Last updated: Apr 6, 2025 Started: Sep 2, 2015 Primary completion: Jun 27, 2021 Completion: Jun 27, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Malignant Melanoma, this trial is completed. The trial is conducted by Prof. Dr. med. Dirk Schadendorf and has accumulated 11 data snapshots since 2015. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Jun 2018 · 17 months · monthly snapshotRecruiting~Jun 2018 – ~Oct 2019 · 16 months · monthly snapshotRecruiting~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshotActive Not Recruiting~Nov 2019 – ~Nov 2020 · 12 months · monthly snapshotActive Not Recruiting~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshotActive Not Recruiting~Jan 2021 – ~Jan 2022 · 12 months · monthly snapshotActive Not Recruiting~Jan 2022 – ~Jul 2024 · 30 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~May 2025 · 8 months · monthly snapshotCompleted~May 2025 – ~Sep 2025 · 4 months · monthly snapshotCompleted~Sep 2025 – present · 10 months · monthly snapshotCompleted

Change History

11 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. May 2025 — Sep 2025 [monthly]

    Completed PHASE2

  3. Sep 2024 — May 2025 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  5. Jan 2022 — Jul 2024 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

Show 6 earlier versions
  1. Jan 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE2

  2. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  3. Nov 2019 — Nov 2020 [monthly]

    Active Not Recruiting PHASE2

  4. Oct 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  5. Jun 2018 — Oct 2019 [monthly]

    Recruiting PHASE2

  6. Jan 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

    First recorded

Sep 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Prof. Dr. med. Dirk Schadendorf
Data source: University Hospital, Essen

For direct contact, visit the study record on ClinicalTrials.gov .