deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT02531516

An Efficacy and Safety Study of JNJ-56021927 (Apalutamide) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy: ATLAS

ATLAS: A Randomized, Double-blind, Placebo-controlled Phase 3 Study of JNJ-56021927 in Subjects With High-risk, Localized or Locally Advanced Prostate Cancer Receiving Treatment With Primary Radiation Therapy

Sponsor: Aragon Pharmaceuticals, Inc.

Conditions Prostatic Neoplasms
Interventions 74-80 Grays (units of radiation) Apalutamide Apalutamide Placebo Bicalutamide Bicalutamide Placebo GnRH (agonist)
Updated 81 times since 2017 Last updated: Feb 12, 2026 Started: Nov 19, 2015 Primary completion: Jun 30, 2026 Completion: Dec 29, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02531516, this PHASE3 trial focuses on Prostatic Neoplasms and remains ongoing. Sponsored by Aragon Pharmaceuticals, Inc., it has been updated 81 times since 2015, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Sep 2017 · 3 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Mar 2018 · 3 months · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Sep 2019 · 3 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Jan 2020 · 3 months · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Oct 2020 · 6 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – present · 6 months · monthly snapshot

Change History

81 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Jan 2026 — Feb 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

  4. Nov 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Oct 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE3

▶ Show 76 earlier versions

  1. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Jun 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE3

  5. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE3

  6. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE3

  7. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

  8. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  9. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

  10. Nov 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

  11. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE3

  12. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  13. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  14. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE3

  15. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  16. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

  17. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE3

  18. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE3

  19. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE3

  20. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  21. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE3

  22. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  23. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  24. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  25. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  26. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  27. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  28. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  29. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  30. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  31. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  32. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  33. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE3

  34. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

  35. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  36. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  37. May 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

  38. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE3

  39. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  40. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE3

  41. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  42. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE3

  43. Nov 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE3

  44. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE3

  45. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE3

  46. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  47. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  48. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE3

  49. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  50. Apr 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE3

  51. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  52. Jan 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE3

  53. Oct 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

  54. Sep 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE3

  55. Jun 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE3

  56. May 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE3

  57. Mar 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE3

  58. Jan 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE3

  59. Dec 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  60. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  61. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  62. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  63. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  64. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  65. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  66. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  67. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE3

  68. Dec 2017 — Mar 2018 [monthly]

    Recruiting PHASE3

  69. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

  70. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE3

  71. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  72. Jun 2017 — Sep 2017 [monthly]

    Recruiting PHASE3

  73. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE3

  74. Apr 2017 — May 2017 [monthly]

    Recruiting PHASE3

  75. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE3

  76. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Nov 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Aragon Pharmaceuticals, Inc.
Data source: Aragon Pharmaceuticals, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aalst, Belgium , Aberdeen, United Kingdom , Adana, Turkey (Türkiye) , Albany, United States , Alkmaar, Netherlands , Amiens, France , Amsterdam, Netherlands , Angers, France , Ankara, Turkey (Türkiye) , Antwerp, Belgium and 253 more locations