deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT02562755

Hepatocellular Carcinoma Study Comparing Vaccinia Virus Based Immunotherapy Plus Sorafenib vs Sorafenib Alone (PHOCUS)

A Phase 3 Randomized, Open-Label Study Comparing Pexa Vec (Vaccinia GM CSF / Thymidine Kinase-Deactivated Virus) Followed by Sorafenib Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC) Without Prior Systemic Therapy

Sponsor: SillaJen, Inc.

Conditions Hepatocellular Carcinoma (HCC)
Interventions Pexastimogene Devacirepvec (Pexa Vec) Sorafenib
Updated 32 times since 2017 Last updated: Dec 11, 2020 Started: Oct 31, 2015 Primary completion: Jul 31, 2020 Completion: Jul 31, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02562755, this PHASE3 trial focuses on Hepatocellular Carcinoma (HCC) and remains completed. Sponsored by SillaJen, Inc., it has been updated 32 times since 2015, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Oct 2017 · 2 months · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Jan 2021 · 16 months · monthly snapshot~Jan 2021 – ~Dec 2022 · 23 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Jul 2024 · 18 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

32 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Jan 2023 — Jul 2024 [monthly]

    Completed PHASE3

▶ Show 27 earlier versions

  1. Dec 2022 — Jan 2023 [monthly]

    Completed PHASE3

  2. Jan 2021 — Dec 2022 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  3. Sep 2019 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  4. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  5. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  6. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  7. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  8. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  9. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  10. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

  11. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  12. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  13. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  14. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  15. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  16. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  17. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE3

  18. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE3

  19. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE3

  20. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

  21. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE3

  22. Aug 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  23. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE3

  24. Jun 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

  25. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE3

  26. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE3

  27. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Oct 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • SillaJen, Inc.
Data source: SillaJen, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aachen, Germany , Adelaide, Australia , Afula, Israel , Ansan, South Korea , Auckland, New Zealand , Baltimore, United States , Bangkok, Thailand , Billings, United States , Birmingham, United Kingdom , Birmingham, United States and 103 more locations