deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT02567409

Cisplatin and Gemcitabine Hydrochloride With or Without Berzosertib in Treating Patients With Metastatic Urothelial Cancer

A Randomized Phase 2 Trial of Cisplatin/Gemcitabine With or Without M6620 (VX-970) in Metastatic Urothelial Carcinoma

Sponsor: National Cancer Institute (NCI)

Updated 53 times since 2017 Last updated: Feb 11, 2025 Started: Jan 31, 2017 Primary completion: Apr 21, 2023 Completion: Apr 25, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Metastatic Bladder Urothelial Carcinoma and Metastatic Renal Pelvis and Ureter Urothelial Carcinoma and is currently completed. National Cancer Institute (NCI) leads this study, which shows 53 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Dec 2017 · 4 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Mar 2019 · 3 months · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Oct 2021 · 5 months · monthly snapshot~Oct 2021 – ~Apr 2022 · 6 months · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~May 2023 · 3 months · monthly snapshot~May 2023 – ~Nov 2023 · 6 months · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Apr 2025 · 5 months · monthly snapshot~Apr 2025 – ~Sep 2025 · 5 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

53 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Apr 2025 — Sep 2025 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  3. Nov 2024 — Apr 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

Show 48 earlier versions
  1. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  3. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Feb 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Dec 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE2

  7. May 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  8. Feb 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE2

  9. Sep 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

  10. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  11. May 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

  12. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE2

  13. Oct 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

  14. May 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE2

  15. Jan 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE2

  16. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  17. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE2

  18. Aug 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

  19. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE2

  20. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE2

  21. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE2

  22. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE2

  23. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE2

  24. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: SuspendedActive Not Recruiting

  25. Jan 2020 — Feb 2020 [monthly]

    Suspended PHASE2

    Status: RecruitingSuspended

  26. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  27. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  28. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  29. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  30. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  31. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  32. Apr 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  33. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  34. Dec 2018 — Mar 2019 [monthly]

    Recruiting PHASE2

  35. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  36. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  37. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  38. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  39. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  40. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  41. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  42. Aug 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  43. Jun 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  44. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  45. Apr 2017 — May 2017 [monthly]

    Recruiting PHASE2

  46. Mar 2017 — Apr 2017 [monthly]

    Recruiting PHASE2

  47. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE2

  48. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .