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Completed PHASE3 INTERVENTIONAL 2-arm NCT02603432

A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN Bladder 100)

A PHASE 3, MULTICENTER, MULTINATIONAL, RANDOMIZED, OPEN-LABEL, PARALLEL-ARM STUDY OF AVELUMAB (MSB0010718C) PLUS BEST SUPPORTIVE CARE VERSUS BEST SUPPORTIVE CARE ALONE AS A MAINTENANCE TREATMENT IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC UROTHELIAL CANCER WHOSE DISEASE DID NOT PROGRESS AFTER COMPLETION OF FIRST-LINE PLATINUM-CONTAINING CHEMOTHERAPY

Sponsor: Pfizer

Conditions Urothelial Cancer
Interventions Avelumab Best Supportive Care Following the planned interim analysis for this study: Avelumab
Updated 42 times since 2017 Last updated: Feb 29, 2024 Started: Apr 25, 2016 Primary completion: Oct 21, 2019 Completion: Mar 28, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02603432, this PHASE3 trial focuses on Urothelial Cancer and remains completed. Sponsored by Pfizer, it has been updated 42 times since 2016, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Oct 2017 · 2 months · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2019 · 13 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Feb 2022 · 2 months · monthly snapshot~Feb 2022 – ~Sep 2022 · 7 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Jul 2023 · 8 months · monthly snapshot~Jul 2023 – ~Apr 2024 · 9 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

42 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Apr 2024 — Jul 2024 [monthly]

    Completed PHASE3

▶ Show 37 earlier versions

  1. Jul 2023 — Apr 2024 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  2. Nov 2022 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  4. Feb 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  5. Dec 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  6. Nov 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE3

  7. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE3

  8. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE3

  9. May 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  10. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE3

  11. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE3

  12. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE3

  13. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  14. Sep 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  15. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

  16. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE3

  17. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  18. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE3

  19. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  20. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  21. Jan 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE3

  22. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

  23. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE3

  24. Sep 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE3

  25. Aug 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  26. Jul 2018 — Aug 2019 [monthly]

    Recruiting PHASE3

  27. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  28. Jan 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  29. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE3

  30. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

  31. Aug 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  32. Jun 2017 — Aug 2017 [monthly]

    Recruiting PHASE3

  33. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE3

  34. Apr 2017 — May 2017 [monthly]

    Recruiting PHASE3

  35. Mar 2017 — Apr 2017 [monthly]

    Recruiting PHASE3

  36. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE3

  37. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Apr 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Pfizer
Data source: Pfizer

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aalborg, Denmark , Aarhus C, Denmark , Aarhus N, Denmark , Ahmedabad, India , Alicante, Spain , Angers, France , Arezzo, Italy , Arnhem, Netherlands , Athens, Greece , Auchenflower, Australia and 197 more locations