deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 2-arm NCT02609776

Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung Cancer (CHRYSALIS)

A Phase 1, First-in-Human, Open-Label, Dose Escalation Study of JNJ-61186372, a Human Bispecific EGFR and cMet Antibody, in Subjects With Advanced Non-Small Cell Lung Cancer

Sponsor: Janssen Research & Development, LLC

Updated 84 times since 2017 Last updated: Jan 15, 2026 Started: May 24, 2016 Primary completion: Dec 31, 2026 Completion: Dec 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Non-Small-Cell Lung Cancer, this trial is ongoing. The trial is conducted by Janssen Research & Development, LLC and has accumulated 84 data snapshots since 2016. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Aug 2017 · 3 months · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Jan 2018 · 4 months · monthly snapshot~Jan 2018 – ~Mar 2018 · 59 days · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jul 2020 · 3 months · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Jun 2021 · 3 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Aug 2023 · 2 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Dec 2023 · 2 months · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Aug 2025 · 2 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

84 versions recorded
  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Jan 2026 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE1

  4. Nov 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Oct 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE1

Show 79 earlier versions
  1. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

  2. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Jun 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

  4. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Mar 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE1

  6. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

  7. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  8. Nov 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE1

  9. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

  10. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1

  11. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  12. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  13. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  14. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE1

  15. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  16. Feb 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

  17. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  18. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  19. Oct 2023 — Dec 2023 [monthly]

    Recruiting PHASE1

  20. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE1

  21. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE1

  22. Jun 2023 — Aug 2023 [monthly]

    Recruiting PHASE1

  23. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE1

  24. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE1

  25. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE1

  26. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE1

  27. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE1

  28. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE1

  29. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  30. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

  31. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  32. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  33. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  34. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  35. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  36. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  37. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  38. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  39. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  40. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  41. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  42. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  43. Mar 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  44. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  45. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  46. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  47. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  48. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  49. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  50. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  51. Apr 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  52. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  53. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  54. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  55. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  56. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  57. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  58. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  59. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  60. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  61. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  62. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  63. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1

  64. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  65. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

  66. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE1

  67. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

  68. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  69. Sep 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  70. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  71. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  72. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

  73. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE1

  74. Jan 2018 — Mar 2018 [monthly]

    Recruiting PHASE1

  75. Sep 2017 — Jan 2018 [monthly]

    Recruiting PHASE1

  76. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE1

  77. May 2017 — Aug 2017 [monthly]

    Recruiting PHASE1

  78. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE1

  79. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

May 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Research & Development, LLC
Data source: Janssen Research & Development, LLC

For direct contact, visit the study record on ClinicalTrials.gov .