deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 9-arm NCT04077463

A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer (Chrysalis-2)

An Open-label Phase 1/1b Study to Evaluate the Safety and Pharmacokinetics of JNJ-73841937 (Lazertinib), a Third Generation EGFR-TKI, as Monotherapy or in Combinations With JNJ-61186372, a Human Bispecific EGFR and cMet Antibody in Participants With Advanced Non-Small Cell Lung Cancer

Sponsor: Janssen Research & Development, LLC

Updated 64 times since 2019 Last updated: Dec 18, 2025 Started: Sep 4, 2019 Primary completion: Jun 3, 2026 Completion: Mar 27, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Carcinoma, Non-Small-Cell Lung, this trial is ongoing. The trial is conducted by Janssen Research & Development, LLC and has accumulated 64 data snapshots since 2019. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Mar 2020 · 3 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~May 2021 · 2 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – present · 8 months · monthly snapshot

Change History

64 versions recorded
  1. Jan 2026 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Nov 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Oct 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

Show 59 earlier versions
  1. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  2. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Jun 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE1

  4. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Mar 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE1

  6. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

  7. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  8. Nov 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  9. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE1

  10. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE1

  11. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  12. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE1

  13. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  14. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE1

  15. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE1

  16. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE1

  17. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE1

  18. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE1

  19. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE1

  20. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE1

  21. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE1

  22. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE1

  23. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE1

  24. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE1

  25. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE1

  26. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE1

  27. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE1

  28. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE1

  29. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE1

  30. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE1

  31. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE1

  32. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  33. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

  34. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  35. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  36. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  37. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  38. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  39. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  40. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  41. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  42. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  43. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  44. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  45. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  46. Mar 2021 — May 2021 [monthly]

    Recruiting PHASE1

  47. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  48. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  49. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  50. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  51. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  52. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  53. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  54. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  55. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  56. Apr 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  57. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  58. Dec 2019 — Mar 2020 [monthly]

    Recruiting PHASE1

  59. Oct 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

    First recorded

Sep 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Research & Development, LLC
Data source: Janssen Research & Development, LLC

For direct contact, visit the study record on ClinicalTrials.gov .