deltatrials
Completed PHASE2 INTERVENTIONAL 3-arm NCT02654990

Panobinostat/Bortezomib/Dexamethasone in Relapsed or Relapsed-and-refractory Multiple Myeloma (PANORAMA_3)

A Multicenter, Randomized, Open-label Phase 2 Study Evaluating the Safety and Efficacy of Three Different Regimens of Oral Panobinostat in Combination With Subcutaneous Bortezomib and Oral Dexamethasone in Patients With Relapsed or Relapsed/Refractory Multiple Myeloma Who Have Been Previously Exposed to Immunomodulatory Agents

Sponsor: pharmaand GmbH

Conditions Multiple Myeloma
Interventions Bortezomib Injection Dexamethasone tablets Panobinostat Capsules
Updated 37 times since 2017 Last updated: Jul 10, 2024 Started: Apr 27, 2016 Primary completion: Oct 18, 2019 Completion: Aug 15, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02654990, this PHASE2 trial focuses on Multiple Myeloma and remains completed. Sponsored by pharmaand GmbH, it has been updated 37 times since 2016, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Jun 2017 · 3 months · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Oct 2017 · 2 months · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Mar 2018 · 3 months · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Nov 2018 · 5 months · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Jan 2020 · 4 months · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Apr 2022 · 12 months · monthly snapshot~Apr 2022 – ~Jul 2023 · 15 months · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Jan 2024 · 3 months · monthly snapshot~Jan 2024 – ~Jul 2024 · 6 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 8 months · monthly snapshot

Change History

37 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Aug 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Jul 2024 — Aug 2024 [monthly]

    Completed PHASE2

  5. Jan 2024 — Jul 2024 [monthly]

    Completed PHASE2

▶ Show 32 earlier versions

  1. Oct 2023 — Jan 2024 [monthly]

    Completed PHASE2

  2. Aug 2023 — Oct 2023 [monthly]

    Completed PHASE2

  3. Jul 2023 — Aug 2023 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  4. Apr 2022 — Jul 2023 [monthly]

    Active Not Recruiting PHASE2

  5. Apr 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

  6. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE2

  7. Sep 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  8. Apr 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE2

  9. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE2

  10. Jan 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  11. Sep 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

  12. Aug 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  13. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  14. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  15. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  16. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  17. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  18. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  19. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  20. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  21. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  22. Jun 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  23. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  24. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE2

  25. Dec 2017 — Mar 2018 [monthly]

    Recruiting PHASE2

  26. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  27. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE2

  28. Aug 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  29. Jun 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  30. Mar 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  31. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE2

  32. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Apr 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • pharmaand GmbH
Data source: pharmaand GmbH

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Amsterdam, Netherlands , Ankara, Turkey (Türkiye) , Athens, Greece , Atlanta, United States , Avignon, France , Bad Saarow, Germany , Bangkok, Thailand , Barcelona, Spain , Barretos, Brazil , Bayonne, France and 63 more locations