deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 3-arm NCT02658890

An Investigational Immuno-therapy Study of BMS-986205 Given in Combination With Nivolumab and in Combination With Both Nivolumab and Ipilimumab in Cancers That Are Advanced or Have Spread

A Phase 1/2a Study of BMS-986205 Administered in Combination With Nivolumab (Anti-PD-1 Monoclonal Antibody) and in Combination With Both Nivolumab and Ipilimumab (Anti-CTLA-4 Monoclonal Antibody) in Advanced Malignant Tumors

Sponsor: Bristol-Myers Squibb

Conditions Advanced Cancer Melanoma Non-Small Cell Lung Cancer
Interventions BMS-986205 Ipilimumab Nivolumab
Updated 27 times since 2017 Last updated: Aug 3, 2023 Started: Apr 14, 2016 Primary completion: Oct 26, 2021 Completion: Oct 26, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02658890, this PHASE1/PHASE2 trial focuses on Advanced Cancer and Melanoma and remains completed. Sponsored by Bristol-Myers Squibb, it has been updated 27 times since 2016, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Jul 2017 · 4 months · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Dec 2017 · 4 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Nov 2018 · 3 months · monthly snapshot~Nov 2018 – ~Mar 2019 · 4 months · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Feb 2020 · 5 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Nov 2021 · 10 months · monthly snapshot~Nov 2021 – ~Sep 2022 · 10 months · monthly snapshot~Sep 2022 – ~Sep 2023 · 12 months · monthly snapshot~Sep 2023 – ~Jul 2024 · 10 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

27 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1/PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  4. Sep 2023 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

  5. Sep 2022 — Sep 2023 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

▶ Show 22 earlier versions

  1. Nov 2021 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  2. Jan 2021 — Nov 2021 [monthly]

    Recruiting PHASE1_PHASE2

  3. Sep 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  4. Jul 2020 — Sep 2020 [monthly]

    Recruiting PHASE1_PHASE2

  5. May 2020 — Jul 2020 [monthly]

    Recruiting PHASE1_PHASE2

  6. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1_PHASE2

  7. Feb 2020 — Apr 2020 [monthly]

    Recruiting PHASE1_PHASE2

  8. Sep 2019 — Feb 2020 [monthly]

    Recruiting PHASE1_PHASE2

  9. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1_PHASE2

  10. Jun 2019 — Aug 2019 [monthly]

    Recruiting PHASE1_PHASE2

  11. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1_PHASE2

  12. Mar 2019 — May 2019 [monthly]

    Recruiting PHASE1_PHASE2

  13. Nov 2018 — Mar 2019 [monthly]

    Recruiting PHASE1_PHASE2

  14. Aug 2018 — Nov 2018 [monthly]

    Recruiting PHASE1_PHASE2

  15. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1_PHASE2

  16. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1_PHASE2

  17. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  18. Aug 2017 — Dec 2017 [monthly]

    Recruiting PHASE1_PHASE2

  19. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE1_PHASE2

  20. Mar 2017 — Jul 2017 [monthly]

    Recruiting PHASE1_PHASE2

  21. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE1_PHASE2

  22. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Apr 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bristol-Myers Squibb
Data source: Bristol-Myers Squibb

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Barcelona, Spain , Brisbane, Australia , Chicago, United States , Clayton, Australia , Cleveland, United States , Detroit, United States , Edmonton, Canada , Essen, Germany , Greenfield Park, Canada and 33 more locations