deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT02720445

Memory Improvement Through Nicotine Dosing (MIND) Study (MIND)

Long-Term Nicotine Treatment of Mild Cognitive Impairment

Sponsor: Alzheimer's Therapeutic Research Institute

Updated 55 times since 2017 Last updated: Sep 25, 2025 Started: Jan 13, 2017 Primary completion: Aug 25, 2025 Completion: Sep 16, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Mild Cognitive Impairment and is currently completed. Alzheimer's Therapeutic Research Institute leads this study, which shows 55 recorded versions since 2017 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~May 2017 · 2 months · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Feb 2018 · 8 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Apr 2022 · 3 months · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Mar 2023 · 3 months · monthly snapshot~Mar 2023 – ~Sep 2023 · 6 months · monthly snapshot~Sep 2023 – ~Jan 2024 · 4 months · monthly snapshot~Jan 2024 – ~Jul 2024 · 6 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Jun 2025 · 5 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – present · 8 months · monthly snapshot

Change History

55 versions recorded
  1. Nov 2025 — Present [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  2. Sep 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Jun 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jan 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Dec 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE2

Show 50 earlier versions
  1. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Jan 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  5. Mar 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  6. Dec 2022 — Mar 2023 [monthly]

    Recruiting PHASE2

  7. Sep 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  8. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  9. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  10. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  11. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  12. Jan 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

  13. Nov 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  14. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  15. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  16. Apr 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  17. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  18. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  19. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  20. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  21. Sep 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  22. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  23. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  24. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  25. Apr 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  26. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  27. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  28. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  29. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  30. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  31. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  32. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  33. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  34. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  35. Apr 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  36. Feb 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  37. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  38. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  39. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  40. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  41. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  42. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  43. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  44. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  45. Feb 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  46. Jun 2017 — Feb 2018 [monthly]

    Recruiting PHASE2

  47. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  48. Mar 2017 — May 2017 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  49. Feb 2017 — Mar 2017 [monthly]

    Not Yet Recruiting PHASE2

  50. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Alzheimer's Therapeutic Research Institute
  • National Institute on Aging (NIA)
  • University of Southern California
  • Vanderbilt University
Data source: University of Southern California

For direct contact, visit the study record on ClinicalTrials.gov .