deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT02750618

Study of the Safety, Pharmacodynamics (PD) and Efficacy of KRN23 in Children From 1 to 4 Years Old With X-linked Hypophosphatemia (XLH)

An Open-Label, Phase 2 Study to Assess the Safety, Pharmacodynamics, and Efficacy of KRN23 in Children From 1 to 4 Years Old With X-linked Hypophosphatemia (XLH)

Sponsor: Kyowa Kirin, Inc.

Interventions Burosumab
Updated 17 times since 2017 Last updated: May 2, 2024 Started: May 5, 2016 Primary completion: Apr 20, 2017 Completion: Sep 10, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02750618, this PHASE2 trial focuses on X-Linked Hypophosphatemia and remains completed. Sponsored by Kyowa Kirin, Inc., it has been updated 17 times since 2016, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Dec 2017 · 6 months · monthly snapshot~Dec 2017 – ~Apr 2018 · 4 months · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Dec 2018 · 5 months · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Nov 2019 · 9 months · monthly snapshot~Nov 2019 – ~Apr 2020 · 5 months · monthly snapshot~Apr 2020 – ~Jan 2021 · 9 months · monthly snapshot~Jan 2021 – ~May 2023 · 28 months · monthly snapshot~May 2023 – ~Jun 2024 · 13 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

17 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Jun 2024 — Jul 2024 [monthly]

    Completed PHASE2

  5. May 2023 — Jun 2024 [monthly]

    Completed PHASE2

Show 12 earlier versions
  1. Jan 2021 — May 2023 [monthly]

    Completed PHASE2

  2. Apr 2020 — Jan 2021 [monthly]

    Completed PHASE2

  3. Nov 2019 — Apr 2020 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  4. Feb 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE2

  5. Dec 2018 — Feb 2019 [monthly]

    Active Not Recruiting PHASE2

  6. Jul 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE2

  7. Jun 2018 — Jul 2018 [monthly]

    Active Not Recruiting PHASE2

  8. Apr 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE2

  9. Dec 2017 — Apr 2018 [monthly]

    Active Not Recruiting PHASE2

  10. Jun 2017 — Dec 2017 [monthly]

    Active Not Recruiting PHASE2

  11. Feb 2017 — Jun 2017 [monthly]

    Active Not Recruiting PHASE2

  12. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE2

    First recorded

May 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Kyowa Kirin, Inc.
Data source: Kyowa Kirin Co., Ltd.

For direct contact, visit the study record on ClinicalTrials.gov .