deltatrials
Completed NA INTERVENTIONAL 2-arm NCT02764320

The MOTS (Medication Overuse Treatment Strategy) Trial (MOTS)

Determining the Optimal Treatment Strategy for Patients Who Have Chronic Migraine With Medication Overuse

Sponsor: Mayo Clinic

Conditions Migraine
Interventions Discontinuation of Overused Medication Migraine Prophylactic Therapy Only
Updated 30 times since 2017 Last updated: Nov 10, 2021 Started: Jan 9, 2017 Primary completion: Mar 31, 2021 Completion: Mar 31, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates Migraine and is currently completed. Mayo Clinic leads this study, which shows 30 recorded versions since 2017 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jul 2017 · 2 months · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Nov 2017 · 2 months · monthly snapshot~Nov 2017 – ~Jan 2018 · 2 months · monthly snapshot~Jan 2018 – ~Mar 2018 · 59 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~May 2019 · 6 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Nov 2019 · 5 months · monthly snapshot~Nov 2019 – ~Mar 2020 · 4 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~May 2021 · 3 months · monthly snapshot~May 2021 – ~Dec 2021 · 7 months · monthly snapshot~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

30 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed NA

  2. Jul 2024 — Sep 2024 [monthly]

    Completed NA

  3. Dec 2021 — Jul 2024 [monthly]

    Completed NA

  4. May 2021 — Dec 2021 [monthly]

    Completed NA

    Status: Active Not Recruiting → Completed

  5. Feb 2021 — May 2021 [monthly]

    Active Not Recruiting NA

    Status: Enrolling By Invitation → Active Not Recruiting

▶ Show 25 earlier versions

  1. Jan 2021 — Feb 2021 [monthly]

    Enrolling By Invitation NA

  2. Dec 2020 — Jan 2021 [monthly]

    Enrolling By Invitation NA

  3. Oct 2020 — Dec 2020 [monthly]

    Enrolling By Invitation NA

  4. Sep 2020 — Oct 2020 [monthly]

    Enrolling By Invitation NA

  5. Apr 2020 — Sep 2020 [monthly]

    Enrolling By Invitation NA

  6. Mar 2020 — Apr 2020 [monthly]

    Enrolling By Invitation NA

  7. Nov 2019 — Mar 2020 [monthly]

    Enrolling By Invitation NA

  8. Jun 2019 — Nov 2019 [monthly]

    Enrolling By Invitation NA

  9. May 2019 — Jun 2019 [monthly]

    Enrolling By Invitation NA

  10. Nov 2018 — May 2019 [monthly]

    Enrolling By Invitation NA

  11. Sep 2018 — Nov 2018 [monthly]

    Enrolling By Invitation NA

  12. Aug 2018 — Sep 2018 [monthly]

    Enrolling By Invitation NA

  13. Jun 2018 — Aug 2018 [monthly]

    Enrolling By Invitation NA

  14. Apr 2018 — Jun 2018 [monthly]

    Enrolling By Invitation NA

  15. Mar 2018 — Apr 2018 [monthly]

    Enrolling By Invitation NA

  16. Jan 2018 — Mar 2018 [monthly]

    Enrolling By Invitation NA

  17. Nov 2017 — Jan 2018 [monthly]

    Enrolling By Invitation NA

  18. Sep 2017 — Nov 2017 [monthly]

    Enrolling By Invitation NA

  19. Aug 2017 — Sep 2017 [monthly]

    Enrolling By Invitation NA

  20. Jul 2017 — Aug 2017 [monthly]

    Enrolling By Invitation NA

  21. May 2017 — Jul 2017 [monthly]

    Enrolling By Invitation NA

  22. Apr 2017 — May 2017 [monthly]

    Enrolling By Invitation NA

  23. Mar 2017 — Apr 2017 [monthly]

    Enrolling By Invitation NA

  24. Feb 2017 — Mar 2017 [monthly]

    Enrolling By Invitation NA

    Status: Not Yet Recruiting → Enrolling By Invitation

  25. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Mayo Clinic
  • Patient-Centered Outcomes Research Institute
Data source: Mayo Clinic

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aurora, United States , Boston, United States , Cincinnati, United States , Cleveland, United States , Dayton, United States , Denver, United States , Flagstaff, United States , Greenwood Village, United States , Hollywood, United States , Jackson, United States and 14 more locations