PfSPZ Challenge in Healthy Malaria-Naïve Adults in the United States
A Phase 1 Dose Escalation Trial to Assess the Safety and Efficacy of Infectious (Replication-intact), Cryopreserved Plasmodium Falciparum Sporozoites (PfSPZ Challenge) Administered by Direct Venous Inoculation Under Chloroquine Cover (PfSPZ-CVac) on Varying Schedules in Healthy Malaria-Naïve Adults in the United States
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Listed as NCT02773979, this PHASE1 trial focuses on Plasmodium Falciparum Infection and remains completed. Sponsored by National Institute of Allergy and Infectious Diseases (NIAID), it has been updated 11 times since 2016, reflecting substantial change activity. This study is part of the global effort to build evidence for infectious disease interventions.
Status Flow
Change History
11 versions recorded-
Sep 2024 — Present [monthly]
Completed PHASE1
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Jul 2024 — Sep 2024 [monthly]
Completed PHASE1
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Jan 2021 — Jul 2024 [monthly]
Completed PHASE1
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Jan 2020 — Jan 2021 [monthly]
Completed PHASE1
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Jun 2018 — Jan 2020 [monthly]
Completed PHASE1
▶ Show 6 earlier versions
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Mar 2018 — Jun 2018 [monthly]
Completed PHASE1
Status: Active Not Recruiting → Completed
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Feb 2018 — Mar 2018 [monthly]
Active Not Recruiting PHASE1
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Dec 2017 — Feb 2018 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
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Mar 2017 — Dec 2017 [monthly]
Recruiting PHASE1
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Feb 2017 — Mar 2017 [monthly]
Recruiting PHASE1
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Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE1
First recorded
Sep 2016
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- National Institute of Allergy and Infectious Diseases (NIAID)
For direct contact, visit the study record on ClinicalTrials.gov .