deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 4-arm NCT02788045

Safety, Tolerability and Immunogenicity Study of Different Vaccine Regimens of Trivalent Ad26.Mos.HIV or Tetravalent Ad26.Mos4.HIV Along With Clade C Glycoprotein (gp)140 in Healthy Human Immunodeficiency Virus (HIV)-Uninfected Adults

A Randomized, Parallel-Group, Placebo-Controlled, Double-Blind Phase 1/2a Study in Healthy HIV Uninfected Adults to Assess the Safety/Tolerability and Immunogenicity of 2 Different Prime/Boost Regimens; Priming With Trivalent Ad26.Mos.HIV and Boosting With Trivalent Ad26.Mos.HIV And Clade C Gp140 Plus Adjuvant or Priming With Tetravalent Ad26.Mos4.HIV and Boosting With Tetravalent Ad26.Mos4.HIV and Clade C Gp140 Plus Adjuvant

Sponsor: Janssen Vaccines & Prevention B.V.

Conditions Healthy
Interventions Ad26.Mos.HIV Ad26.Mos4.HIV Clade C gp140 Placebo
Updated 37 times since 2017 Last updated: May 22, 2025 Started: Jul 8, 2016 Primary completion: Apr 25, 2022 Completion: Apr 25, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1/PHASE2 clinical study on Healthy, this trial is completed. The trial is conducted by Janssen Vaccines & Prevention B.V. and has accumulated 37 data snapshots since 2016. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~Jul 2017 · 3 months · monthly snapshot~Jul 2017 – ~Mar 2018 · 8 months · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jan 2019 · 7 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Sep 2019 · 4 months · monthly snapshot~Sep 2019 – ~Jan 2020 · 4 months · monthly snapshot~Jan 2020 – ~Apr 2020 · 3 months · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Dec 2020 · 5 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Oct 2021 · 7 months · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Jul 2023 · 10 months · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – present · 13 months · monthly snapshot

Change History

37 versions recorded

  1. Jun 2025 — Present [monthly]

    Completed PHASE1/PHASE2

  2. May 2025 — Jun 2025 [monthly]

    Completed PHASE1/PHASE2

  3. Apr 2025 — May 2025 [monthly]

    Completed PHASE1/PHASE2

  4. Mar 2025 — Apr 2025 [monthly]

    Completed PHASE1/PHASE2

  5. Sep 2024 — Mar 2025 [monthly]

    Completed PHASE1/PHASE2

▶ Show 32 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  2. Aug 2023 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

  3. Jul 2023 — Aug 2023 [monthly]

    Completed PHASE1_PHASE2

  4. Sep 2022 — Jul 2023 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

  5. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  6. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  7. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  8. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  9. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  10. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  11. Nov 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  12. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  13. Mar 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  14. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  15. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  16. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  17. Jul 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  18. May 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  19. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  20. Jan 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  21. Sep 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  22. May 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  23. Apr 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  24. Feb 2019 — Apr 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  25. Jan 2019 — Feb 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Phase: PHASE2 → PHASE1_PHASE2

  26. Jun 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE2

  27. May 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  28. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE2

  29. Jul 2017 — Mar 2018 [monthly]

    Recruiting PHASE2

  30. Apr 2017 — Jul 2017 [monthly]

    Recruiting PHASE2

  31. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE2

  32. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Jul 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Vaccines & Prevention B.V.
Data source: Janssen Vaccines & Prevention B.V.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations