deltatrials
Completed PHASE3 INTERVENTIONAL 4-arm NCT02847637

A Clinical Trial to Evaluate Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants Without Inhibitors (HAVEN 3)

A Randomized, Multicenter, Open-Label, Phase III Clinical Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Patients Without Inhibitors

Sponsor: Chugai Pharmaceutical

Conditions Hemophilia A
Interventions Emicizumab Factor VIII (FVIII)
Updated 28 times since 2017 Last updated: Oct 19, 2022 Started: Sep 27, 2016 Primary completion: Sep 15, 2017 Completion: May 12, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Hemophilia A, this trial is completed. The trial is conducted by Chugai Pharmaceutical and has accumulated 28 data snapshots since 2016. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Sep 2017 · 3 months · monthly snapshot~Sep 2017 – ~Dec 2017 · 3 months · monthly snapshot~Dec 2017 – ~Feb 2018 · 2 months · monthly snapshot~Feb 2018 – ~May 2018 · 3 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Dec 2018 · 4 months · monthly snapshot~Dec 2018 – ~Mar 2019 · 3 months · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Aug 2019 · 3 months · monthly snapshot~Aug 2019 – ~Nov 2019 · 3 months · monthly snapshot~Nov 2019 – ~Feb 2020 · 3 months · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Aug 2020 · 3 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Mar 2022 · 6 months · monthly snapshot~Mar 2022 – ~Jun 2022 · 3 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Dec 2022 · 5 months · monthly snapshot~Dec 2022 – ~Jul 2024 · 19 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

28 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Dec 2022 — Jul 2024 [monthly]

    Completed PHASE3

  5. Jul 2022 — Dec 2022 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

▶ Show 23 earlier versions

  1. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

  2. Mar 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE3

  4. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  5. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  6. Aug 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE3

  7. May 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE3

  8. Feb 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  9. Nov 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  10. Aug 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE3

  11. May 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE3

  12. Mar 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE3

  13. Dec 2018 — Mar 2019 [monthly]

    Active Not Recruiting PHASE3

  14. Aug 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE3

  15. Jun 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE3

  16. May 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  17. Feb 2018 — May 2018 [monthly]

    Active Not Recruiting PHASE3

  18. Dec 2017 — Feb 2018 [monthly]

    Active Not Recruiting PHASE3

  19. Sep 2017 — Dec 2017 [monthly]

    Active Not Recruiting PHASE3

  20. Jun 2017 — Sep 2017 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  21. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE3

  22. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE3

  23. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Sep 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Chugai Pharmaceutical
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Adelaide, Australia , Aichi, Japan , Atlanta, United States , Bonn, Germany , Boston, United States , Bron, France , Cardiff, United Kingdom , Chang-hua, Taiwan , Detroit, United States , Dublin, Ireland and 28 more locations