deltatrials
Terminated PHASE1/PHASE2 INTERVENTIONAL 2-arm NCT02859415

Continuous 24h Intravenous Infusion of Mithramycin, an Inhibitor of Cancer Stem Cell Signaling, in People With Primary Thoracic Malignancies or Carcinomas, Sarcomas or Germ Cell Neoplasms With Pleuropulmonary Metastases

Phase I/II Evaluation of Continuous 24h Intravenous Infusion of Mithramycin, an Inhibitor of Cancer Stem Cell Signaling, in Patients With Primary Thoracic Malignancies or Carcinomas, Sarcomas or Germ Cell Neoplasms With Pleuropulmonary Metastases

Sponsor: National Cancer Institute (NCI)

Conditions Esophageal Neoplasms Lung Neoplasms Mesothelioma Neoplasms, Germ Cell and Embryonal Thymus Neoplasms
Interventions Mithramycin
Updated 24 times since 2017 Last updated: Mar 10, 2022 Started: Aug 8, 2019 Primary completion: Dec 6, 2019 Completion: Dec 1, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Slow/Insufficient accrual

Other terminated trials from National Cancer Institute (NCI)

See all terminations from National Cancer Institute (NCI)

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Browse all Esophageal Neoplasms trials

A PHASE1/PHASE2 clinical study on Esophageal Neoplasms and Lung Neoplasms, this trial is terminated or withdrawn. The trial is conducted by National Cancer Institute (NCI) and has accumulated 24 data snapshots since 2019. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~Aug 2017 · 4 months · monthly snapshot~Aug 2017 – ~Jan 2018 · 5 months · monthly snapshot~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Dec 2018 · 4 months · monthly snapshot~Dec 2018 – ~May 2019 · 5 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Dec 2020 · 7 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Oct 2021 · 8 months · monthly snapshot~Oct 2021 – ~Jan 2022 · 3 months · monthly snapshot~Jan 2022 – ~May 2022 · 4 months · monthly snapshot~May 2022 – ~Jul 2024 · 26 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

24 versions recorded

  1. Sep 2024 — Present [monthly]

    Terminated PHASE1/PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  3. May 2022 — Jul 2024 [monthly]

    Terminated PHASE1_PHASE2

  4. Jan 2022 — May 2022 [monthly]

    Terminated PHASE1_PHASE2

    Status: Recruiting → Terminated

  5. Oct 2021 — Jan 2022 [monthly]

    Recruiting PHASE1_PHASE2

▶ Show 19 earlier versions

  1. Feb 2021 — Oct 2021 [monthly]

    Recruiting PHASE1_PHASE2

  2. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1_PHASE2

  3. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  4. May 2020 — Dec 2020 [monthly]

    Recruiting PHASE1_PHASE2

  5. Feb 2020 — May 2020 [monthly]

    Recruiting PHASE1_PHASE2

  6. Dec 2019 — Feb 2020 [monthly]

    Recruiting PHASE1_PHASE2

  7. Oct 2019 — Dec 2019 [monthly]

    Recruiting PHASE1_PHASE2

  8. Aug 2019 — Oct 2019 [monthly]

    Recruiting PHASE1_PHASE2

  9. Jun 2019 — Aug 2019 [monthly]

    Recruiting PHASE1_PHASE2

  10. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Suspended → Recruiting

  11. Dec 2018 — May 2019 [monthly]

    Suspended PHASE1_PHASE2

  12. Aug 2018 — Dec 2018 [monthly]

    Suspended PHASE1_PHASE2

    Status: Recruiting → Suspended

  13. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1_PHASE2

  14. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1_PHASE2

  15. Jan 2018 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  16. Aug 2017 — Jan 2018 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Not Yet Recruiting → Recruiting

  17. Apr 2017 — Aug 2017 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    Status: Recruiting → Not Yet Recruiting

  18. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE1_PHASE2

  19. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations