deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT02890355

FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic Cancer

Randomized Phase II Study of 2nd Line FOLFIRI Versus Modified FOLFIRI With PARP Inhibitor ABT-888 (Veliparib) (NSC-737664) in Metastatic Pancreatic Cancer

Sponsor: National Cancer Institute (NCI)

Conditions Metastatic Pancreatic Adenocarcinoma Recurrent Pancreatic Carcinoma Stage IV Pancreatic Cancer AJCC v6 and v7
Interventions Fluorouracil Irinotecan Hydrochloride Laboratory Biomarker Analysis Leucovorin Calcium Veliparib
Updated 79 times since 2017 Last updated: Mar 4, 2026 Started: Sep 1, 2016 Primary completion: May 1, 2019 Completion: Mar 17, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02890355, this PHASE2 trial focuses on Metastatic Pancreatic Adenocarcinoma and Recurrent Pancreatic Carcinoma and remains ongoing. Sponsored by National Cancer Institute (NCI), it has been updated 79 times since 2016, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Aug 2019 · 3 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Oct 2020 · 8 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Jan 2022 · 3 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Jan 2024 · 2 months · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Aug 2025 · 2 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Mar 2026 · 59 days · monthly snapshot~Mar 2026 – present · 4 months · monthly snapshot

Change History

79 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Jan 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE2

  4. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 74 earlier versions

  1. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  2. Jun 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE2

  3. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE2

  6. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

  7. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE2

  8. Dec 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE2

  9. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

  10. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2

  11. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2

  12. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  13. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  14. Mar 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  15. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  16. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE2

  17. Nov 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

  18. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  19. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

  20. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE2

  21. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE2

  22. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE2

  23. Apr 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2

  24. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE2

  25. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE2

  26. Dec 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

  27. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

  28. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  29. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

  30. Apr 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE2

  31. Feb 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

  32. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE2

  33. Oct 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE2

  34. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE2

  35. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  36. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE2

  37. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE2

  38. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE2

  39. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE2

  40. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE2

  41. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  42. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE2

  43. Feb 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

  44. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE2

  45. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE2

  46. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE2

  47. Oct 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE2

  48. Sep 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE2

  49. Aug 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE2

  50. May 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE2

  51. Apr 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE2

  52. Mar 2019 — Apr 2019 [monthly]

    Active Not Recruiting PHASE2

  53. Feb 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE2

  54. Jan 2019 — Feb 2019 [monthly]

    Active Not Recruiting PHASE2

  55. Dec 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE2

  56. Nov 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE2

  57. Oct 2018 — Nov 2018 [monthly]

    Active Not Recruiting PHASE2

  58. Sep 2018 — Oct 2018 [monthly]

    Active Not Recruiting PHASE2

  59. Aug 2018 — Sep 2018 [monthly]

    Active Not Recruiting PHASE2

  60. Jul 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE2

  61. Jun 2018 — Jul 2018 [monthly]

    Active Not Recruiting PHASE2

  62. Jan 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  63. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE2

  64. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  65. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE2

  66. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  67. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE2

  68. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  69. Jun 2017 — Jul 2017 [monthly]

    Recruiting PHASE2

  70. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  71. Apr 2017 — May 2017 [monthly]

    Recruiting PHASE2

  72. Mar 2017 — Apr 2017 [monthly]

    Recruiting PHASE2

  73. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE2

  74. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Sep 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aberdeen, United States , Abington, United States , Adrian, United States , Albuquerque, United States , Allentown, United States , Ames, United States , Anaconda, United States , Anacortes, United States , Anaheim, United States , Anchorage, United States and 468 more locations