deltatrials
Recruiting PHASE1 INTERVENTIONAL 2-arm NCT02897063

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

The Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure Aim 2 of RDCRN (Rare Diseases Clinical Research Network) Project 2

Sponsor: Vanderbilt University Medical Center

Conditions Autonomic Failure Multiple System Atrophy Orthostatic Hypotension Parkinson Disease Pure Autonomic Failure
Interventions Droxidopa Midodrine Placebo
Updated 16 times since 2017 Last updated: Oct 8, 2025 Started: Sep 30, 2016 Primary completion: Sep 30, 2026 Completion: Dec 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02897063, this PHASE1 trial focuses on Autonomic Failure and Multiple System Atrophy and remains actively recruiting participants. Sponsored by Vanderbilt University Medical Center, it has been updated 16 times since 2016, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Mar 2019 · 9 months · monthly snapshot~Mar 2019 – ~Mar 2020 · 12 months · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Oct 2020 · 5 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Jul 2022 · 10 months · monthly snapshot~Jul 2022 – ~Sep 2023 · 14 months · monthly snapshot~Sep 2023 – ~Apr 2024 · 7 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Nov 2025 · 10 months · monthly snapshot~Nov 2025 – present · 10 months · monthly snapshot

Change History

16 versions recorded

  1. Nov 2025 — Present [monthly]

    Recruiting PHASE1

  2. Jan 2025 — Nov 2025 [monthly]

    Recruiting PHASE1

  3. Sep 2024 — Jan 2025 [monthly]

    Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  5. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

▶ Show 11 earlier versions

  1. Sep 2023 — Apr 2024 [monthly]

    Recruiting PHASE1

  2. Jul 2022 — Sep 2023 [monthly]

    Recruiting PHASE1

  3. Sep 2021 — Jul 2022 [monthly]

    Recruiting PHASE1

  4. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  5. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  6. May 2020 — Oct 2020 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  7. Mar 2020 — May 2020 [monthly]

    Recruiting PHASE1

  8. Mar 2019 — Mar 2020 [monthly]

    Recruiting PHASE1

  9. Jun 2018 — Mar 2019 [monthly]

    Recruiting PHASE1

  10. Feb 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

    Phase: NA → PHASE1

  11. Jan 2017 — Feb 2017 [monthly]

    Recruiting NA

    First recorded

Sep 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Vanderbilt University Medical Center
Data source: Vanderbilt University Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations