deltatrials
Completed PHASE1 INTERVENTIONAL 2-arm NCT02906371

Study of the Tocilizumab Optimization Timing for CART19 Associated Cytokine Release Syndrome

A Two Cohort Pilot Study of the Tocilizumab Optimization Timing for CART19 Associated Cytokine Release Syndrome (CRS) Management in Pediatric Patients With CD19 Expressing Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia (ALL)

Sponsor: Children's Hospital of Philadelphia

Updated 11 times since 2017 Last updated: Jun 30, 2021 Started: Aug 31, 2016 Primary completion: Mar 11, 2020 Completion: Jun 30, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Lymphoblastic Leukemia, Acute, Childhood, this trial is completed. The trial is conducted by Children's Hospital of Philadelphia and has accumulated 11 data snapshots since 2016. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotRecruiting~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshotRecruiting~Jun 2018 – ~Apr 2019 · 10 months · monthly snapshotRecruiting~Apr 2019 – ~Dec 2019 · 8 months · monthly snapshotActive Not Recruiting~Dec 2019 – ~Oct 2020 · 10 months · monthly snapshotActive Not Recruiting~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshotActive Not Recruiting~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshotActive Not Recruiting~Feb 2021 – ~Sep 2021 · 7 months · monthly snapshotActive Not Recruiting~Sep 2021 – ~Jul 2024 · 34 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – present · 22 months · monthly snapshotCompleted

Change History

11 versions recorded
  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Sep 2021 — Jul 2024 [monthly]

    Completed PHASE1

    Status: Active Not RecruitingCompleted

  4. Feb 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

    Phase: NAPHASE1

  5. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting NA

Show 6 earlier versions
  1. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting NA

  2. Dec 2019 — Oct 2020 [monthly]

    Active Not Recruiting NA

  3. Apr 2019 — Dec 2019 [monthly]

    Active Not Recruiting NA

    Status: RecruitingActive Not Recruiting

  4. Jun 2018 — Apr 2019 [monthly]

    Recruiting NA

  5. Feb 2017 — Jun 2018 [monthly]

    Recruiting NA

  6. Jan 2017 — Feb 2017 [monthly]

    Recruiting NA

    First recorded

Aug 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Children's Hospital of Philadelphia
  • University of Pennsylvania
Data source: University of Pennsylvania

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations