deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT02924727

Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI (PARADISE-MI)

A Multi-center, Randomized, Double-blind, Active-controlled, Parallel-group Phase 3 Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Ramipril on Morbidity and Mortality in High Risk Patients Following an Acute Myocardial Infarction (AMI)

Sponsor: Novartis Pharmaceuticals

Conditions Acute Myocardial Infarction
Interventions LCZ696 (sacubitril/valsartan) Placebo of LCZ696 Placebo of ramipril Placebo of valsartan Ramipril Valsartan
Updated 36 times since 2017 Last updated: Jun 16, 2023 Started: Dec 9, 2016 Primary completion: Feb 26, 2021 Completion: Feb 26, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Acute Myocardial Infarction and is currently completed. Novartis Pharmaceuticals leads this study, which shows 36 recorded versions since 2016 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Dec 2017 · 6 months · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Feb 2020 · 3 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Sep 2020 · 3 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Jun 2021 · 3 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Jul 2023 · 22 months · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Feb 2026 · 2 months · monthly snapshot~Feb 2026 – present · 7 months · monthly snapshot

Change History

36 versions recorded

  1. Feb 2026 — Present [monthly]

    Completed PHASE3

  2. Dec 2025 — Feb 2026 [monthly]

    Completed PHASE3

  3. Nov 2025 — Dec 2025 [monthly]

    Completed PHASE3

  4. Sep 2025 — Nov 2025 [monthly]

    Completed PHASE3

  5. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

▶ Show 31 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  2. Jul 2023 — Jul 2024 [monthly]

    Completed PHASE3

  3. Sep 2021 — Jul 2023 [monthly]

    Completed PHASE3

  4. Jun 2021 — Sep 2021 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  5. Mar 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

  6. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE3

  7. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  8. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  9. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

    Status: Active Not Recruiting → Recruiting

  10. Jun 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  11. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  12. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE3

  13. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE3

  14. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  15. Nov 2019 — Feb 2020 [monthly]

    Recruiting PHASE3

  16. Sep 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  17. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  18. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  19. Apr 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  20. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  21. Jan 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  22. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  23. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  24. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  25. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  26. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  27. Jan 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  28. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE3

  29. Jun 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

  30. Feb 2017 — Jun 2017 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  31. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Dec 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novartis Pharmaceuticals
Data source: Novartis

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

A Coruña, Spain , Aalborg, Denmark , Aalst, Belgium , Ahmedabad, India , Alexandria, United States , Alexandroupoli, Greece , Alkmaar, Netherlands , Almada, Portugal , Almelo, Netherlands , Amersfoort, Netherlands and 394 more locations